Norepinephrine Induces PTSD-Like Memory Impairments via Regulation of the β-Adrenoceptor-cAMP/PKA and CaMK II/PKC Systems in the Basolateral Amygdala

• Published in: Frontiers in behavioral neuroscience Vol. 13; p. 43
• Main Authors: Liu, Xiang-Hui, Zhu, Rong-Ting, Hao, Bo, Shi, Yan-Wei, Wang, Xiao-Guang, Xue, Li, Zhao, Hu
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 06.03.2019; Frontiers Media S.A
• Subjects: Adrenergic receptors; AMPA; Amygdala; Arousal; basolateral amygdala; Ca2+/calmodulin-dependent protein kinase II; cAMP/PKA; Cyclic AMP; Drug dosages; fear conditioning; Forensic medicine; Glucocorticoids; Glutamic acid receptors (ionotropic); Kinases; Laboratory animals; Memory; Neurobiology; Neuroscience; Norepinephrine; Phosphorylation; Post traumatic stress disorder; Propranolol; Protein kinase A; Protein kinase C; PTSD; Rodents; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors; China; PTSD; norepinephrine; AMPA; fear conditioning; cAMP/PKA; basolateral amygdala; CaMK II/PKC
• ISSN: 1662-5153; 1662-5153
• DOI: 10.3389/fnbeh.2019.00043

Glucocorticoids (GCs) can modulate the memory enhancement process during stressful events, and this modulation requires arousal-induced norepinephrine (NE) activation in the basolateral amygdale (BLA). Our previous study found that an intrahippocampal infusion of propranolol dose-dependently induced post-traumatic stress disorder (PTSD)-like memory impairments. To explore the role of the noradrenergic system of the BLA in PTSD-like memory impairment, we injected various doses of NE into the BLA. We found that only a specific quantity of NE (0.3 μg) could induce PTSD-like memory impairments, accompanied by a reduction in phosphorylation of GluR1 at Ser845 and Ser831. Moreover, this phenomenon could be blocked by a protein kinase A (PKA) inhibitor or calcium/calmodulin-dependent protein kinase II (CaMK II) inhibitor. These findings demonstrate that NE could induce PTSD-like memory impairments regulation of the β-adrenoceptor receptor (β-AR)-3',5'-cyclic monophosphate (cAMP)/PKA and CaMK II/PKC signaling pathways.