Mucus Is a Key Factor in Neisseria meningitidis Commensalism

The work presented by Audry et al. (M. Audry, C. Robbe-Masselot, J.-P. Barnier, B. Gachet, et al., mSphere 4:e00494-19, 2019, https://doi.org/10.1128/mSphere.00494-19) gives new insight into the interactions of and the human nasopharynx. Using an air interface tissue culture model of a polarized, mu...

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Bibliographic Details
Published inmSphere Vol. 4; no. 6
Main Authors Callaghan, Melanie M, Dillard, Joseph P
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 04.12.2019
Subjects
Bacteria
Cell culture
commensal
Commensalism
Epithelial Cells
Epithelium
Gene expression
Host-Microbe Biology
Humans
Immune response
Inflammation
Meningitis
Microbiota
Mucous Membrane
Mucus
Nasopharynx
Neisseria meningitidis
Pathogens
Streptococcus infections
Studies
Symbiosis
Tissue culture
United States > US
Wisconsin
Neisseria meningitidis
commensal
mucus
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Summary:The work presented by Audry et al. (M. Audry, C. Robbe-Masselot, J.-P. Barnier, B. Gachet, et al., mSphere 4:e00494-19, 2019, https://doi.org/10.1128/mSphere.00494-19) gives new insight into the interactions of and the human nasopharynx. Using an air interface tissue culture model of a polarized, mucus-secreting epithelium, Audry et al. demonstrate that bacteria do not commonly invade epithelial cells. Rather, they are trapped in the mucus layer, where they are protected from dessication. In this model, meningicocci fail to elicit a pro-inflammatory immune response and show growth effects in response to another nasopharyngeal colonizer, These findings prompt new questions about pathobiont behaviors, the role of mucus in bacterium-host interactions, and modeling human infection.
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Citation Callaghan MM, Dillard JP. 2019. Mucus is a key factor in Neisseria meningitidis commensalism. mSphere 4:e00777-19. https://doi.org/10.1128/mSphere.00777-19.
For the article discussed, see https://doi.org/10.1128/mSphere.00494-19.
ISSN:2379-5042
2379-5042
DOI:10.1128/msphere.00777-19