Less efficient pattern separation may contribute to age-related spatial memory deficits

• Published in: Frontiers in aging neuroscience Vol. 4; p. 9
• Main Authors: Holden, Heather M, Gilbert, Paul E
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 2012; Frontiers Media S.A
• Subjects: Aging; Animal memory; Cognitive ability; Dentate Gyrus; Hippocampus; interference; Memory; Neurodegenerative diseases; Neuroscience; Pattern Separation; Spatial memory; dentate gyrus; pattern separation; aging; interference; hippocampus; spatial memory

Spatial memory deficits have been well-documented in older adults and may serve as an early indicator of mild cognitive impairment (MCI) or Alzheimer's disease (AD) in some individuals. Pattern separation is a critical mechanism for reducing potential interference among similar memory represent...