Less efficient pattern separation may contribute to age-related spatial memory deficits

Spatial memory deficits have been well-documented in older adults and may serve as an early indicator of mild cognitive impairment (MCI) or Alzheimer's disease (AD) in some individuals. Pattern separation is a critical mechanism for reducing potential interference among similar memory represent...

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Bibliographic Details
Published inFrontiers in aging neuroscience Vol. 4; p. 9
Main Authors Holden, Heather M, Gilbert, Paul E
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 2012
Frontiers Media S.A
Subjects
Aging
Animal memory
Cognitive ability
Dentate Gyrus
Hippocampus
interference
Memory
Neurodegenerative diseases
Neuroscience
Pattern Separation
Spatial memory
dentate gyrus
pattern separation
aging
interference
hippocampus
spatial memory
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Summary:Spatial memory deficits have been well-documented in older adults and may serve as an early indicator of mild cognitive impairment (MCI) or Alzheimer's disease (AD) in some individuals. Pattern separation is a critical mechanism for reducing potential interference among similar memory representations to enhance memory accuracy. A small but growing literature indicates that spatial pattern separation may become less efficient as a result of normal aging, possibly due to age-related changes in subregions of the hippocampus. This decreased efficiency in spatial pattern separation may be a critical processing deficit that could be a contributing factor to spatial memory deficits and episodic memory impairment associated with aging. The present paper will review recently published studies in humans, non-human primates, and rodents that have examined age-related changes in spatial pattern separation. The potential basic science, translational, and clinical implications from these studies are discussed to illustrate the need for future research to further examine the relationship between spatial pattern separation and brain changes associated with aging and neurodegenerative disease.
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Edited by: Emma R. Wood, University of Edinburgh, UK
Reviewed by: Junming Wang, University of Mississippi Medical Center, USA; Ashok Kumar, University of Florida, USA
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2012.00009