Long non‑coding RNA GAS5 in human cancer (Review)

Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth....

Full description

Saved in:
Bibliographic Details
Published inOncology letters Vol. 20; no. 3; pp. 2587 - 2594
Main Authors Yang, Xiaoyan, Xie, Zhizhong, Lei, Xiaoyong, Gan, Runliang
Format Journal Article
LanguageEnglish
Published Athens Spandidos Publications 01.09.2020
Spandidos Publications UK Ltd
D.A. Spandidos
Subjects
Androgens
Apoptosis
Bladder cancer
Bone cancer
Breast cancer
Cancer metastasis
Cancer research
Cancer therapies
Cell cycle
Cell division
Cell growth
Cervical cancer
Colorectal cancer
Digestive system cancer
Disease
Endometrial cancer
Esophageal cancer
Gastric cancer
Genes
Glioma
Gliomas
Kidney cancer
Lapatinib
Liver cancer
Lung cancer
Lymphatic system
Medical diagnosis
Medical prognosis
Melanoma
Metastasis
Mortality
Oncology
Ovarian cancer
Pancreatic cancer
Prostate cancer
Review
RNA
Sarcoma
Skin cancer
Squamous cell carcinoma
Stomach cancer
Thyroid cancer
Thyroid diseases
Tumors
Online AccessGet full text
ISSN1792-1074
1792-1082
DOI10.3892/ol.2020.11809

Cover

Abstract Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth. The present study focused on growth arrest-specific transcript 5 (GAS5), a well-known lncRNA that acts as a tumor suppressor but is suppressed in multiple types of cancer, including mammary carcinoma, prostate cancer, colorectal cancer, gastric cancer, melanoma, esophageal squamous cell carcinoma, lung cancer, ovarian cancer, cervical cancer, gliomas, osteosarcoma, pancreatic cancer, bladder cancer, kidney cancer, papillary thyroid carcinoma, neuroblastoma, endometrial cancer and liver cancer. Notably, GAS5 is overexpressed in liver cancer, potentially functioning as an oncogene. In the present study, the diagnostic and therapeutic roles of GAS5 in different tumors were reviewed, with a summary of the potential clinical application of the lncRNA, which may help identify novel study directions for GAS5. Key words: long non-coding RNA, GAS5, tumor suppressor gene, diagnostic biomarker, therapeutic targe
AbstractList Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth. The present study focused on growth arrest-specific transcript 5 (GAS5), a well-known lncRNA that acts as a tumor suppressor but is suppressed in multiple types of cancer, including mammary carcinoma, prostate cancer, colorectal cancer, gastric cancer, melanoma, esophageal squamous cell carcinoma, lung cancer, ovarian cancer, cervical cancer, gliomas, osteosarcoma, pancreatic cancer, bladder cancer, kidney cancer, papillary thyroid carcinoma, neuroblastoma, endometrial cancer and liver cancer. Notably, GAS5 is overexpressed in liver cancer, potentially functioning as an oncogene. In the present study, the diagnostic and therapeutic roles of GAS5 in different tumors were reviewed, with a summary of the potential clinical application of the lncRNA, which may help identify novel study directions for GAS5.
Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth. The present study focused on growth arrest-specific transcript 5 (GAS5), a well-known lncRNA that acts as a tumor suppressor but is suppressed in multiple types of cancer, including mammary carcinoma, prostate cancer, colorectal cancer, gastric cancer, melanoma, esophageal squamous cell carcinoma, lung cancer, ovarian cancer, cervical cancer, gliomas, osteosarcoma, pancreatic cancer, bladder cancer, kidney cancer, papillary thyroid carcinoma, neuroblastoma, endometrial cancer and liver cancer. Notably, GAS5 is overexpressed in liver cancer, potentially functioning as an oncogene. In the present study, the diagnostic and therapeutic roles of GAS5 in different tumors were reviewed, with a summary of the potential clinical application of the lncRNA, which may help identify novel study directions for GAS5.Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth. The present study focused on growth arrest-specific transcript 5 (GAS5), a well-known lncRNA that acts as a tumor suppressor but is suppressed in multiple types of cancer, including mammary carcinoma, prostate cancer, colorectal cancer, gastric cancer, melanoma, esophageal squamous cell carcinoma, lung cancer, ovarian cancer, cervical cancer, gliomas, osteosarcoma, pancreatic cancer, bladder cancer, kidney cancer, papillary thyroid carcinoma, neuroblastoma, endometrial cancer and liver cancer. Notably, GAS5 is overexpressed in liver cancer, potentially functioning as an oncogene. In the present study, the diagnostic and therapeutic roles of GAS5 in different tumors were reviewed, with a summary of the potential clinical application of the lncRNA, which may help identify novel study directions for GAS5.
Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth. The present study focused on growth arrest-specific transcript 5 (GAS5), a well-known lncRNA that acts as a tumor suppressor but is suppressed in multiple types of cancer, including mammary carcinoma, prostate cancer, colorectal cancer, gastric cancer, melanoma, esophageal squamous cell carcinoma, lung cancer, ovarian cancer, cervical cancer, gliomas, osteosarcoma, pancreatic cancer, bladder cancer, kidney cancer, papillary thyroid carcinoma, neuroblastoma, endometrial cancer and liver cancer. Notably, GAS5 is overexpressed in liver cancer, potentially functioning as an oncogene. In the present study, the diagnostic and therapeutic roles of GAS5 in different tumors were reviewed, with a summary of the potential clinical application of the lncRNA, which may help identify novel study directions for GAS5. Key words: long non-coding RNA, GAS5, tumor suppressor gene, diagnostic biomarker, therapeutic targe
Audience Academic
Author Gan, Runliang
Yang, Xiaoyan
Xie, Zhizhong
Lei, Xiaoyong
AuthorAffiliation 2 Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, P.R. China
3 Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan 421001, P.R. China
1 Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China
AuthorAffiliation_xml – name: 1 Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China
– name: 2 Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, P.R. China
– name: 3 Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan 421001, P.R. China
Author_xml – sequence: 1
  givenname: Xiaoyan
  surname: Yang
  fullname: Yang, Xiaoyan
  organization: Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China
– sequence: 2
  givenname: Zhizhong
  surname: Xie
  fullname: Xie, Zhizhong
  organization: Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, P.R. China
– sequence: 3
  givenname: Xiaoyong
  surname: Lei
  fullname: Lei, Xiaoyong
  organization: Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, P.R. China
– sequence: 4
  givenname: Runliang
  surname: Gan
  fullname: Gan, Runliang
  organization: Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China
BookMark eNptkttKHTEUhkOx1EO97P2AIHox25wmmdwIG1Fb2FSw9jpkkszekUyikxnFO1_BV-yTNFOt7RYTyGHl-_9FkrUNNkIMFoAvCM5ILfBR9DMMMZwhVEPxAWwhLnCJYI03XtecboLdlK5hbhVDdc0-gU2CeY0rzrYAWcSwLLLtr8cnHY3Lm8vv8-J8_qMqXChWY6dCoVXQti8OLu2ds_eHn8HHVvlkd1_mHfDz7PTq5Gu5uDj_djJflJoKOJRct0YLBRvMamYaYkzTtlRxAhWGWkBjGywwN5ShlguCtMYNU9ROAZOlZAccP_vejE1njbZh6JWXN73rVP8go3Jy_SS4lVzGO8kphIKzbHDwYtDH29GmQXYuaeu9CjaOSWJKCKZQ1CSje2_Q6zj2IV9vojARiOLqH7VU3koX2pjz6slUzhkhFavykKnZO1TuxnZO5x9sXY6vCfb_E6ys8sMqRT8OLoa0DpJnUPcxpd62UrtBTVjO4LxEUE51IaOXU13IP3WRVeUb1d8nfJ__DcmYtsw
CitedBy_id crossref_primary_10_2174_1389557521666211101161548
crossref_primary_10_1007_s11356_023_26996_1
crossref_primary_10_2217_epi_2020_0449
crossref_primary_10_1016_j_heliyon_2023_e23826
crossref_primary_10_3390_biomedicines12050932
crossref_primary_10_3390_ijms22136810
crossref_primary_10_1016_j_cytogfr_2022_06_001
crossref_primary_10_1080_14737140_2024_2341737
crossref_primary_10_1134_S1022795424700029
crossref_primary_10_1038_s41366_024_01555_x
crossref_primary_10_3389_fimmu_2022_897754
crossref_primary_10_1097_MD_0000000000039414
crossref_primary_10_1016_j_asjsur_2021_08_031
crossref_primary_10_1016_j_intimp_2021_108105
crossref_primary_10_1016_j_ncrna_2021_11_001
crossref_primary_10_1186_s13000_021_01108_0
crossref_primary_10_31857_S0016675824050063
crossref_primary_10_2147_CMAR_S297868
crossref_primary_10_3390_ncrna7010001
crossref_primary_10_1016_j_tiv_2022_105321
crossref_primary_10_1016_j_prp_2023_154851
crossref_primary_10_1080_14737159_2023_2195554
crossref_primary_10_3389_fphar_2021_779606
crossref_primary_10_1038_s41598_024_51732_1
crossref_primary_10_3389_fonc_2022_965628
crossref_primary_10_3390_ijms22083923
crossref_primary_10_3390_ijms25105538
crossref_primary_10_1155_2022_8051717
crossref_primary_10_1615_CritRevEukaryotGeneExpr_2022042373
crossref_primary_10_3389_fonc_2021_765216
crossref_primary_10_3390_cancers13236102
crossref_primary_10_3389_fphys_2022_949498
crossref_primary_10_1007_s12672_024_01051_8
crossref_primary_10_1016_j_cca_2025_120265
crossref_primary_10_1007_s00018_023_04842_4
crossref_primary_10_1016_j_prp_2022_153856
crossref_primary_10_61229_mpj_v2i1_32
crossref_primary_10_2298_VSP220412075M
crossref_primary_10_3390_ijms25084548
crossref_primary_10_3390_ijerph19169971
crossref_primary_10_2147_OTT_S266435
crossref_primary_10_3390_ijms22189767
crossref_primary_10_3390_ijms21249742
crossref_primary_10_1016_j_cca_2021_01_019
crossref_primary_10_61186_rbmb_12_3_487
crossref_primary_10_1007_s12032_025_02643_2
crossref_primary_10_1093_carcin_bgad073
crossref_primary_10_1038_s41417_021_00313_9
crossref_primary_10_1038_s41598_023_36568_5
crossref_primary_10_33073_pjm_2024_040
crossref_primary_10_1093_bib_bbab504
crossref_primary_10_3390_ijms241210201
crossref_primary_10_3389_fcell_2022_818416
crossref_primary_10_7759_cureus_77527
crossref_primary_10_2174_0929867328666211027123932
crossref_primary_10_3390_ijms25052670
crossref_primary_10_12677_ACM_2022_124527
crossref_primary_10_3390_ijms25115690
crossref_primary_10_1007_s10528_024_10997_x
crossref_primary_10_1016_j_prp_2024_155424
crossref_primary_10_3390_ijms21207633
crossref_primary_10_3390_ijms22052683
crossref_primary_10_1016_j_bbadis_2024_167206
crossref_primary_10_1016_j_prp_2024_155223
crossref_primary_10_1093_bib_bbac154
crossref_primary_10_3390_onco1020014
crossref_primary_10_1016_j_ncrna_2024_12_005
crossref_primary_10_3390_ncrna9010012
crossref_primary_10_12677_WJCR_2023_132013
crossref_primary_10_3389_fonc_2021_710538
crossref_primary_10_1016_j_ejphar_2023_175520
crossref_primary_10_2147_BTT_S454058
crossref_primary_10_1016_j_ncrna_2024_06_015
crossref_primary_10_1016_j_bbagen_2024_130567
crossref_primary_10_3389_fcell_2022_1060909
crossref_primary_10_3892_or_2022_8334
crossref_primary_10_2174_1566524022666220509122505
crossref_primary_10_1016_j_gene_2025_149217
crossref_primary_10_3892_mmr_2022_12735
crossref_primary_10_3389_fsurg_2022_848831
crossref_primary_10_3892_ol_2023_13925
Cites_doi 10.1158/1541-7786.MCR-16-0331
10.3892/or.2015.4318
10.1128/MCB.18.12.6897
10.3748/wjg.v19.i34.5598
10.1016/j.suc.2019.09.013
10.1007/s13277-015-4111-x
10.1007/978-1-61779-612-8_26
10.1371/journal.pone.0105538
10.1007/s13277-015-3915-z
10.1093/bioinformatics/btt426
10.1242/jcs.024646
10.1371/journal.pone.0073991
10.1159/000433499
10.1038/nrg3606
10.1159/000487178
10.1080/15384101.2018.1475826
10.18632/oncotarget.14244
10.1016/j.clinthera.2016.03.026
10.1007/s13277-015-4521-9
10.1007/s00432-018-2820-4
10.1038/nm.3981
10.1186/1471-2407-14-319
10.1016/j.ygyno.2019.10.025
10.1016/S0092-8674(88)91065-3
10.1007/s00441-013-1711-x
10.1007/s10620-017-4831-4
10.1186/s12967-015-0592-z
10.3892/mmr.2015.4716
10.1016/j.ijbiomac.2018.12.176
10.1097/BRS.0b013e31822576a4
10.1038/srep11338
10.18632/oncotarget.23336
10.1016/S0140-6736(16)30354-3
10.1016/j.bbrc.2017.11.119
10.1158/1055-9965.EPI-05-0029
10.3727/096504016X14822800040451
10.1186/1897-4287-10-18
10.1186/s12929-015-0213-4
10.1093/carcin/bgv099
10.1002/jcp.26889
10.1038/nrg2521
10.3322/caac.21442
10.1111/j.1440-1746.2007.04991.x
10.1016/j.nbd.2013.05.011
10.1002/mc.22120
10.3322/caac.21254
10.1016/j.nbd.2012.06.004
10.12659/MSM.910867
10.1136/gutjnl-2014-308124
10.1128/MCB.12.8.3514
10.3892/ol.2017.5841
10.1007/s12032-014-0253-8
10.1016/j.bbadis.2013.05.005
10.3892/ijo.2016.3377
10.3322/caac.21492
10.1016/j.ccell.2016.03.010
10.1038/mt.2015.170
10.1007/s11060-015-1718-0
10.1371/journal.pone.0182305
10.1002/(SICI)1098-2795(199711)48:3<310::AID-MRD2>3.0.CO;2-U
10.1136/gutjnl-2014-308392
10.1016/j.celrep.2016.01.062
10.3389/fbioe.2015.00077
10.1016/j.omtn.2018.09.026
10.1177/1087057115583448
10.1016/j.ygyno.2018.08.032
10.1002/jcb.26145
10.1038/cdd.2013.110
10.1038/s41419-018-0264-z
10.1097/IGC.0000000000001028
10.1038/onc.2008.373
10.3322/caac.20107
10.1126/scisignal.2000568
10.1159/000491718
10.18632/oncotarget.8413
ContentType Journal Article
Copyright COPYRIGHT 2020 Spandidos Publications
Copyright Spandidos Publications UK Ltd. 2020
Copyright: © Yang et al.
Copyright: © Yang et al. 2020
Copyright_xml – notice: COPYRIGHT 2020 Spandidos Publications
– notice: Copyright Spandidos Publications UK Ltd. 2020
– notice: Copyright: © Yang et al.
– notice: Copyright: © Yang et al. 2020
DBID AAYXX
CITATION
3V.
7X7
7XB
8FI
8FJ
8FK
ABUWG
AFKRA
AN0
BENPR
CCPQU
FYUFA
GHDGH
K9.
M0S
PHGZM
PHGZT
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOI 10.3892/ol.2020.11809
DatabaseName CrossRef
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
British Nursing Database
ProQuest Central
ProQuest One Community College
ProQuest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
British Nursing Index with Full Text
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
ProQuest One Health & Nursing
Health Research Premium Collection (Alumni)
ProQuest Central China
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Central (New)
ProQuest One Academic
ProQuest Central (Alumni)
ProQuest One Academic (New)
MEDLINE - Academic
DatabaseTitleList ProQuest One Academic Middle East (New)

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: 7X7
  name: Health & Medical Collection
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1792-1082
EndPage 2594
ExternalDocumentID PMC7400976
A633565335
10_3892_ol_2020_11809
GroupedDBID ---
0R~
53G
7X7
8FI
8FJ
AAKDD
AAYXX
ABDBF
ABJNI
ABUWG
ACGFS
ACUHS
ADBBV
AENEX
AFKRA
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AN0
BENPR
BNQBC
BPHCQ
BVXVI
C45
CCPQU
CITATION
EBD
EBS
EJD
ESX
F5P
FYUFA
H13
HMCUK
HUR
HZ~
IAO
IHR
IHW
IPNFZ
ITC
O9-
OK1
OVD
PHGZM
PHGZT
PQQKQ
PROAC
RIG
RPM
TEORI
UKHRP
W2D
PMFND
3V.
7XB
8FK
K9.
PKEHL
PPXIY
PQEST
PQUKI
PRINS
7X8
PUEGO
5PM
ID FETCH-LOGICAL-c490t-7cfdc9a0b2686db3ddbff4a730a20c90deb2927d461f7931cc2b6a4ed461dfdc3
IEDL.DBID 7X7
ISSN 1792-1074
IngestDate Thu Aug 21 18:40:57 EDT 2025
Thu Sep 04 16:57:01 EDT 2025
Fri Jul 25 22:33:58 EDT 2025
Tue Jun 17 21:43:05 EDT 2025
Tue Jun 10 20:43:49 EDT 2025
Thu May 22 21:15:38 EDT 2025
Thu Apr 24 23:02:25 EDT 2025
Tue Jul 01 01:58:55 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed false
IsScholarly true
Issue 3
Language English
License This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c490t-7cfdc9a0b2686db3ddbff4a730a20c90deb2927d461f7931cc2b6a4ed461dfdc3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC7400976
PMID 32782576
PQID 2432391425
PQPubID 2044954
PageCount 8
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7400976
proquest_miscellaneous_2433240983
proquest_journals_2432391425
gale_infotracmisc_A633565335
gale_infotracacademiconefile_A633565335
gale_healthsolutions_A633565335
crossref_citationtrail_10_3892_ol_2020_11809
crossref_primary_10_3892_ol_2020_11809
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-09-01
PublicationDateYYYYMMDD 2020-09-01
PublicationDate_xml – month: 09
  year: 2020
  text: 2020-09-01
  day: 01
PublicationDecade 2020
PublicationPlace Athens
PublicationPlace_xml – name: Athens
PublicationTitle Oncology letters
PublicationYear 2020
Publisher Spandidos Publications
Spandidos Publications UK Ltd
D.A. Spandidos
Publisher_xml – name: Spandidos Publications
– name: Spandidos Publications UK Ltd
– name: D.A. Spandidos
References Van Cutsem (key20220302135148_b3-ol-0-0-11809) 2016; 388
Theis (key20220302135148_b7-ol-0-0-11809) 2015; 20
Chang (key20220302135148_b86-ol-0-0-11809) 2016; 13
Cao (key20220302135148_b65-ol-0-0-11809) 2014; 7
Cheng (key20220302135148_b41-ol-0-0-11809) 2018; 40
Lu (key20220302135148_b30-ol-0-0-11809) 2013; 354
Liu (key20220302135148_b48-ol-0-0-11809) 2016
Liu (key20220302135148_b81-ol-0-0-11809) 2019; 18
Mourtada-Maarabouni (key20220302135148_b16-ol-0-0-11809) 2009; 28
Sun (key20220302135148_b17-ol-0-0-11809) 2014; 14
Zhang (key20220302135148_b33-ol-0-0-11809) 2013; 20
Jemal (key20220302135148_b34-ol-0-0-11809) 2011; 61
Correa (key20220302135148_b46-ol-0-0-11809) 2005; 14
Zhang (key20220302135148_b56-ol-0-0-11809) 2013; 19
Siegel (key20220302135148_b52-ol-0-0-11809) 2015; 65
Coccia (key20220302135148_b19-ol-0-0-11809) 1992; 12
Zabaleta (key20220302135148_b44-ol-0-0-11809) 2012; 863
Liu (key20220302135148_b72-ol-0-0-11809) 2015; 122
Sun (key20220302135148_b49-ol-0-0-11809) 2014; 14
Chen (key20220302135148_b54-ol-0-0-11809) 2016; 48
Gao (key20220302135148_b69-ol-0-0-11809) 2019; 126
Gu (key20220302135148_b31-ol-0-0-11809) 2018; 48
Fleming (key20220302135148_b20-ol-0-0-11809) 1997; 48
Li (key20220302135148_b32-ol-0-0-11809) 2016; 7
Liu (key20220302135148_b77-ol-0-0-11809) 2018; 13
Sun (key20220302135148_b26-ol-0-0-11809) 2014; 14
Zhang (key20220302135148_b71-ol-0-0-11809) 2013; 58
Mazar (key20220302135148_b84-ol-0-0-11809) 2017; 8
Ye (key20220302135148_b75-ol-0-0-11809) 2017; 118
Shi (key20220302135148_b24-ol-0-0-11809) 2015; 54
Sun (key20220302135148_b53-ol-0-0-11809) 2020; 100
Mercer (key20220302135148_b10-ol-0-0-11809) 2009; 10
Zhang (key20220302135148_b39-ol-0-0-11809) 2017; 12
Miyahara (key20220302135148_b43-ol-0-0-11809) 2007; 22
Wang (key20220302135148_b76-ol-0-0-11809) 2018; 45
Wang (key20220302135148_b79-ol-0-0-11809) 2018; 9
Liu (key20220302135148_b80-ol-0-0-11809) 2013; 8
Zugazagoitia (key20220302135148_b2-ol-0-0-11809) 2016; 38
Xie (key20220302135148_b37-ol-0-0-11809) 2019; 18
Zhang (key20220302135148_b70-ol-0-0-11809) 2012; 48
McComas (key20220302135148_b62-ol-0-0-11809) 2020; 156
Yang (key20220302135148_b42-ol-0-0-11809) 2017; 13
Liu (key20220302135148_b29-ol-0-0-11809) 2013; 8
Wen (key20220302135148_b66-ol-0-0-11809) 2017; 27
Zhao (key20220302135148_b63-ol-0-0-11809) 2018; 151
Pickard (key20220302135148_b18-ol-0-0-11809) 2013; 1832
Zhang (key20220302135148_b83-ol-0-0-11809) 2017; 9
Smith (key20220302135148_b22-ol-0-0-11809) 1998; 18
Bray (key20220302135148_b1-ol-0-0-11809) 2018; 68
Wang (key20220302135148_b59-ol-0-0-11809) 2018; 495
Zhao (key20220302135148_b73-ol-0-0-11809) 2015; 23
Vogelaar (key20220302135148_b45-ol-0-0-11809) 2012; 10
Abbah (key20220302135148_b38-ol-0-0-11809) 2011; 36
Ma (key20220302135148_b4-ol-0-0-11809) 2016; 65
Kino (key20220302135148_b28-ol-0-0-11809) 2010; 3
Zhang (key20220302135148_b50-ol-0-0-11809) 2016; 20
Pickard (key20220302135148_b35-ol-0-0-11809) 2013; 1832
Shi (key20220302135148_b61-ol-0-0-11809) 2015; 54
Xue (key20220302135148_b15-ol-0-0-11809) 2016; 37
Yin (key20220302135148_b27-ol-0-0-11809) 2014; 31
Chen (key20220302135148_b55-ol-0-0-11809) 2019; 145
Siegel (key20220302135148_b40-ol-0-0-11809) 2018; 68
Guo (key20220302135148_b85-ol-0-0-11809) 2015; 22
Ruan (key20220302135148_b5-ol-0-0-11809) 2016; 14
Liu (key20220302135148_b74-ol-0-0-11809) 2018; 234
Zhang (key20220302135148_b14-ol-0-0-11809) 2014; 9
Tao (key20220302135148_b88-ol-0-0-11809) 2015; 36
Schmitt (key20220302135148_b12-ol-0-0-11809) 2016; 29
Chen (key20220302135148_b8-ol-0-0-11809) 2013; 29
Li (key20220302135148_b51-ol-0-0-11809) 2017; 62
Veneziano (key20220302135148_b6-ol-0-0-11809) 2015; 3
Dong (key20220302135148_b82-ol-0-0-11809) 2018; 8
Wang (key20220302135148_b58-ol-0-0-11809) 2018; 24
Zheng (key20220302135148_b68-ol-0-0-11809) 2015; 13
Fatica (key20220302135148_b11-ol-0-0-11809) 2014; 15
Ma (key20220302135148_b67-ol-0-0-11809) 2012; 125
Arnold (key20220302135148_b57-ol-0-0-11809) 2015; 64
Huarte (key20220302135148_b13-ol-0-0-11809) 2015; 21
Hu (key20220302135148_b87-ol-0-0-11809) 2016; 37
Luo (key20220302135148_b36-ol-0-0-11809) 2017; 15
Mourtada-Maarabouni (key20220302135148_b25-ol-0-0-11809) 2008; 121
Guo (key20220302135148_b47-ol-0-0-11809) 2015; 38
Chen (key20220302135148_b9-ol-0-0-11809) 2015; 5
Lu (key20220302135148_b78-ol-0-0-11809) 2013; 354
Mei (key20220302135148_b60-ol-0-0-11809) 2017; 25
Schneider (key20220302135148_b21-ol-0-0-11809) 1988; 54
Gao (key20220302135148_b64-ol-0-0-11809) 2015; 34
Ma (key20220302135148_b23-ol-0-0-11809) 2016; 37
References_xml – volume: 15
  start-page: 789
  year: 2017
  ident: key20220302135148_b36-ol-0-0-11809
  article-title: LncRNA GAS5 inhibits cellular proliferation by targeting P27Kip1
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-16-0331
– volume: 34
  start-page: 3212
  year: 2015
  ident: key20220302135148_b64-ol-0-0-11809
  article-title: Long non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway
  publication-title: Oncol Rep
  doi: 10.3892/or.2015.4318
– volume: 18
  start-page: 6897
  year: 1998
  ident: key20220302135148_b22-ol-0-0-11809
  article-title: Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5′-terminal oligopyrimidine gene family reveals common features of snoRNA host genes
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.18.12.6897
– volume: 19
  start-page: 5598
  year: 2013
  ident: key20220302135148_b56-ol-0-0-11809
  article-title: Epidemiology of esophageal cancer
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v19.i34.5598
– volume: 100
  start-page: 175
  year: 2020
  ident: key20220302135148_b53-ol-0-0-11809
  article-title: Principles of targeted therapy for melanoma
  publication-title: Surg Clin North Am
  doi: 10.1016/j.suc.2019.09.013
– volume: 37
  start-page: 2691
  year: 2016
  ident: key20220302135148_b87-ol-0-0-11809
  article-title: Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21
  publication-title: Tumour Biol
  doi: 10.1007/s13277-015-4111-x
– volume: 863
  start-page: 411
  year: 2012
  ident: key20220302135148_b44-ol-0-0-11809
  article-title: Multifactorial etiology of gastric cancer
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-61779-612-8_26
– volume: 9
  start-page: e105538
  year: 2014
  ident: key20220302135148_b14-ol-0-0-11809
  article-title: Long noncoding RNA HOTAIR as an independent prognostic marker in cancer: A meta-analysis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0105538
– volume: 37
  start-page: 1211
  year: 2016
  ident: key20220302135148_b15-ol-0-0-11809
  article-title: Prognostic value of long non-coding RNA MALAT1 in various carcinomas: Evidence from nine studies
  publication-title: Tumour Biol
  doi: 10.1007/s13277-015-3915-z
– volume: 29
  start-page: 2617
  year: 2013
  ident: key20220302135148_b8-ol-0-0-11809
  article-title: Novel human lncRNA-disease association inference based on lncRNA expression profiles
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt426
– volume: 121
  start-page: 939
  year: 2008
  ident: key20220302135148_b25-ol-0-0-11809
  article-title: Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5)
  publication-title: J Cell Sci
  doi: 10.1242/jcs.024646
– volume: 8
  start-page: e73991
  year: 2013
  ident: key20220302135148_b80-ol-0-0-11809
  article-title: Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0073991
– volume: 38
  start-page: 362
  year: 2015
  ident: key20220302135148_b47-ol-0-0-11809
  article-title: GAS5 Inhibits gastric cancer cell proliferation partly by modulating CDK6
  publication-title: Oncol Res Treat
  doi: 10.1159/000433499
– volume: 15
  start-page: 7
  year: 2014
  ident: key20220302135148_b11-ol-0-0-11809
  article-title: Long non-coding RNAs: New players in cell differentiation and development
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg3606
– volume: 45
  start-page: 844
  year: 2018
  ident: key20220302135148_b76-ol-0-0-11809
  article-title: LncRNA GAS5 represses osteosarcoma cells growth and metastasis via sponging MiR-203a
  publication-title: Cell Physiol Biochem
  doi: 10.1159/000487178
– volume: 18
  start-page: 257
  year: 2019
  ident: key20220302135148_b81-ol-0-0-11809
  article-title: Long non-coding RNA GAS5 sensitizes renal cell carcinoma to sorafenib via miR-21/SOX5 pathway
  publication-title: Cell Cycle
  doi: 10.1080/15384101.2018.1475826
– volume: 8
  start-page: 6589
  year: 2017
  ident: key20220302135148_b84-ol-0-0-11809
  article-title: The long non-coding RNA GAS5 differentially regulates cell cycle arrest and apoptosis through activation of BRCA1 and p53 in human neuroblastoma
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.14244
– volume: 38
  start-page: 1551
  year: 2016
  ident: key20220302135148_b2-ol-0-0-11809
  article-title: Current challenges in cancer treatment
  publication-title: Clin Ther
  doi: 10.1016/j.clinthera.2016.03.026
– volume: 37
  start-page: 1437
  year: 2016
  ident: key20220302135148_b23-ol-0-0-11809
  article-title: The growth arrest-specific transcript 5 (GAS5): A pivotal tumor suppressor long non-coding RNA in human cancers
  publication-title: Tumour Biol
  doi: 10.1007/s13277-015-4521-9
– volume: 145
  start-page: 637
  year: 2019
  ident: key20220302135148_b55-ol-0-0-11809
  article-title: LncRNA GAS5 regulates redox balance and dysregulates the cell cycle and apoptosis in malignant melanoma cells
  publication-title: J Cancer Res Clin Oncol
  doi: 10.1007/s00432-018-2820-4
– volume: 21
  start-page: 1253
  year: 2015
  ident: key20220302135148_b13-ol-0-0-11809
  article-title: The emerging role of lncRNAs in cancer
  publication-title: Nat Med
  doi: 10.1038/nm.3981
– volume: 14
  start-page: 319
  year: 2014
  ident: key20220302135148_b49-ol-0-0-11809
  article-title: Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-14-319
– volume: 156
  start-page: 85
  year: 2020
  ident: key20220302135148_b62-ol-0-0-11809
  article-title: The variable impact of positive lymph nodes in cervical cancer: Implications of the new FIGO staging system
  publication-title: Gynecol Oncol
  doi: 10.1016/j.ygyno.2019.10.025
– volume: 8
  start-page: e73991
  year: 2013
  ident: key20220302135148_b29-ol-0-0-11809
  article-title: Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0073991
– volume: 54
  start-page: 787
  year: 1988
  ident: key20220302135148_b21-ol-0-0-11809
  article-title: Genes specifically expressed at growth arrest of mammalian cells
  publication-title: Cell
  doi: 10.1016/S0092-8674(88)91065-3
– volume: 354
  start-page: 891
  year: 2013
  ident: key20220302135148_b78-ol-0-0-11809
  article-title: Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6
  publication-title: Cell Tissue Res
  doi: 10.1007/s00441-013-1711-x
– volume: 62
  start-page: 3426
  year: 2017
  ident: key20220302135148_b51-ol-0-0-11809
  article-title: The GAS5/miR-222 axis regulates proliferation of gastric cancer cells through the PTEN/ Akt/ mTOR pathway
  publication-title: Dig Dis Sci
  doi: 10.1007/s10620-017-4831-4
– volume: 13
  start-page: 252
  year: 2015
  ident: key20220302135148_b68-ol-0-0-11809
  article-title: MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer
  publication-title: J Transl Med
  doi: 10.1186/s12967-015-0592-z
– volume: 13
  start-page: 1541
  year: 2016
  ident: key20220302135148_b86-ol-0-0-11809
  article-title: Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation and invasion in hepatocellular carcinoma by regulating vimentin
  publication-title: Mol Med Rep
  doi: 10.3892/mmr.2015.4716
– volume: 126
  start-page: 994
  year: 2019
  ident: key20220302135148_b69-ol-0-0-11809
  article-title: LncRNA GAS5 confers the radio sensitivity of cervical cancer cells via regulating miR-106b/IER3 axis
  publication-title: Int J Biol Macromol
  doi: 10.1016/j.ijbiomac.2018.12.176
– volume: 36
  start-page: 1752
  year: 2011
  ident: key20220302135148_b38-ol-0-0-11809
  article-title: Fusion performance of low-dose recombinant human bone morphogenetic protein 2 and bone marrow-derived multipotent stromal cells in biodegradable scaffolds: A comparative study in a large animal model of anterior lumbar interbody fusion
  publication-title: Spine
  doi: 10.1097/BRS.0b013e31822576a4
– volume: 5
  start-page: 11338
  year: 2015
  ident: key20220302135148_b9-ol-0-0-11809
  article-title: Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity
  publication-title: Sci Rep
  doi: 10.1038/srep11338
– volume: 9
  start-page: 3519
  year: 2017
  ident: key20220302135148_b83-ol-0-0-11809
  article-title: LncRNA Gas5 acts as a ceRNA to regulate PTEN expression by sponging miR-222-3p in papillary thyroid carcinoma
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.23336
– volume: 388
  start-page: 2654
  year: 2016
  ident: key20220302135148_b3-ol-0-0-11809
  article-title: Gastric cancer
  publication-title: Lancet
  doi: 10.1016/S0140-6736(16)30354-3
– volume: 495
  start-page: 1151
  year: 2018
  ident: key20220302135148_b59-ol-0-0-11809
  article-title: Negative regulation of lncRNA GAS5 by miR-196a inhibits esophageal squamous cell carcinoma growth
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2017.11.119
– volume: 14
  start-page: 319
  year: 2014
  ident: key20220302135148_b26-ol-0-0-11809
  article-title: Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-14-319
– volume: 14
  start-page: 319
  year: 2014
  ident: key20220302135148_b17-ol-0-0-11809
  article-title: Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-14-319
– volume: 8
  start-page: 1414
  year: 2018
  ident: key20220302135148_b82-ol-0-0-11809
  article-title: GAS5 functions as a ceRNA to regulate hZIP1 expression by sponging miR-223 in clear cell renal cell carcinoma
  publication-title: Am J Cancer Res
– volume: 14
  start-page: 1865
  year: 2005
  ident: key20220302135148_b46-ol-0-0-11809
  article-title: Etiology of gastric cancer: What is new?
  publication-title: Cancer Epidemiol Biomarkers Prev
  doi: 10.1158/1055-9965.EPI-05-0029
– volume: 25
  start-page: 1027
  year: 2017
  ident: key20220302135148_b60-ol-0-0-11809
  article-title: Long non-coding RNA GAS5 suppresses tumorigenesis by inhibiting miR-23a expression in non-small cell lung cancer
  publication-title: Oncol Res
  doi: 10.3727/096504016X14822800040451
– volume: 10
  start-page: 18
  year: 2012
  ident: key20220302135148_b45-ol-0-0-11809
  article-title: Familial gastric cancer: Detection of a hereditary cause helps to understand its etiology
  publication-title: Hered Cancer Clin Pract
  doi: 10.1186/1897-4287-10-18
– volume: 22
  start-page: 100
  year: 2015
  ident: key20220302135148_b85-ol-0-0-11809
  article-title: LncRNA-GAS5 induces PTEN expression through inhibiting miR-103 in endometrial cancer cells
  publication-title: J Biomed Sci
  doi: 10.1186/s12929-015-0213-4
– volume: 36
  start-page: 1136
  year: 2015
  ident: key20220302135148_b88-ol-0-0-11809
  article-title: Association between indel polymorphism in the promoter region of lncRNA GAS5 and the risk of hepatocellular carcinoma
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgv099
– volume: 234
  start-page: 757
  year: 2018
  ident: key20220302135148_b74-ol-0-0-11809
  article-title: Long non-coding RNA GAS5 regulates the proliferation, migration, and invasion of glioma cells by negatively regulating miR-18a-5p
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.26889
– volume: 7
  start-page: 6776
  year: 2014
  ident: key20220302135148_b65-ol-0-0-11809
  article-title: Decreased expression of lncRNA GAS5 predicts a poor prognosis in cervical cancer
  publication-title: Int J Clin Exp Pathol
– volume: 10
  start-page: 155
  year: 2009
  ident: key20220302135148_b10-ol-0-0-11809
  article-title: Long non-coding RNAs: Insights into functions
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2521
– volume: 68
  start-page: 7
  year: 2018
  ident: key20220302135148_b40-ol-0-0-11809
  article-title: Cancer statistics, 2018
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21442
– volume: 354
  start-page: 891
  year: 2013
  ident: key20220302135148_b30-ol-0-0-11809
  article-title: Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6
  publication-title: Cell Tissue Res
  doi: 10.1007/s00441-013-1711-x
– volume: 22
  start-page: 1435
  year: 2007
  ident: key20220302135148_b43-ol-0-0-11809
  article-title: Prevalence and prognosis of gastric cancer detected by screening in a large Japanese population: Data from a single institute over 30 years
  publication-title: J Gastroenterol Hepatol
  doi: 10.1111/j.1440-1746.2007.04991.x
– volume: 58
  start-page: 123
  year: 2013
  ident: key20220302135148_b71-ol-0-0-11809
  article-title: A long non-coding RNA signature in glioblastoma multiforme predicts survival
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2013.05.011
– volume: 40
  start-page: 2371
  year: 2018
  ident: key20220302135148_b41-ol-0-0-11809
  article-title: lncRNA GAS5 inhibits colorectal cancer cell proliferation via the miR-182-5p/FOXO3a axis
  publication-title: Oncol Rep
– volume: 54
  start-page: E1
  year: 2015
  ident: key20220302135148_b24-ol-0-0-11809
  article-title: A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer
  publication-title: Mol Carcinog
  doi: 10.1002/mc.22120
– volume: 18
  start-page: 1043
  year: 2019
  ident: key20220302135148_b37-ol-0-0-11809
  article-title: MicroRNA-145 inhibits proliferation and induces apoptosis in human prostate carcinoma by upregulating long non-coding RNA GAS5
  publication-title: Oncol Lett
– volume: 65
  start-page: 5
  year: 2015
  ident: key20220302135148_b52-ol-0-0-11809
  article-title: Cancer statistics, 2015
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21254
– volume: 48
  start-page: 1
  year: 2012
  ident: key20220302135148_b70-ol-0-0-11809
  article-title: Long non-coding RNA expression profiles predict clinical phenotypes in glioma
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2012.06.004
– volume: 125
  start-page: 4270
  year: 2012
  ident: key20220302135148_b67-ol-0-0-11809
  article-title: Profiling of microRNA-mRNA reveals roles of microRNAs in cervical cancer
  publication-title: Chin Med J (Engl)
– volume: 24
  start-page: 7689
  year: 2018
  ident: key20220302135148_b58-ol-0-0-11809
  article-title: Long non-coding RNA (lncRNA) Growth Arrest Specific 5 (GAS5) suppresses esophageal squamous cell carcinoma cell proliferation and migration by inactivating phosphatidylinositol 3-kinase (PI3K)/AKT Mammalian Target of Rapamycin (mTOR) signaling pathway
  publication-title: Med Sci Monit
  doi: 10.12659/MSM.910867
– volume: 64
  start-page: 381
  year: 2015
  ident: key20220302135148_b57-ol-0-0-11809
  article-title: Global incidence of oesophageal cancer by histological subtype in 2012
  publication-title: Gut
  doi: 10.1136/gutjnl-2014-308124
– volume: 12
  start-page: 3514
  year: 1992
  ident: key20220302135148_b19-ol-0-0-11809
  article-title: Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.12.8.3514
– volume: 13
  start-page: 3151
  year: 2017
  ident: key20220302135148_b42-ol-0-0-11809
  article-title: Long non-coding RNA GAS5 inhibits cell proliferation, induces G0/G1 arrest and apoptosis, and functions as a prognostic marker in colorectal cancer
  publication-title: Oncol Lett
  doi: 10.3892/ol.2017.5841
– volume: 20
  start-page: 3199
  year: 2016
  ident: key20220302135148_b50-ol-0-0-11809
  article-title: GAS5 is downregulated in gastric cancer cells by promoter hypermethylation and regulates adriamycin sensitivity
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 31
  start-page: 253
  year: 2014
  ident: key20220302135148_b27-ol-0-0-11809
  article-title: Long non-coding RNA GAS5 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer
  publication-title: Med Oncol
  doi: 10.1007/s12032-014-0253-8
– volume: 1832
  start-page: 1613
  year: 2013
  ident: key20220302135148_b18-ol-0-0-11809
  article-title: Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbadis.2013.05.005
– volume: 48
  start-page: 1509
  year: 2016
  ident: key20220302135148_b54-ol-0-0-11809
  article-title: Lentiviral-mediated overexpression of long non-coding RNA GAS5 reduces invasion by mediating MMP2 expression and activity in human melanoma cells
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2016.3377
– volume: 68
  start-page: 394
  year: 2018
  ident: key20220302135148_b1-ol-0-0-11809
  article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21492
– volume: 29
  start-page: 452
  year: 2016
  ident: key20220302135148_b12-ol-0-0-11809
  article-title: Long noncoding rnas in cancer pathways
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.03.010
– volume: 23
  start-page: 1899
  year: 2015
  ident: key20220302135148_b73-ol-0-0-11809
  article-title: Gas5 exerts tumor-suppressive functions in human glioma cells by targeting miR-222
  publication-title: Mol Ther
  doi: 10.1038/mt.2015.170
– volume: 122
  start-page: 283
  year: 2015
  ident: key20220302135148_b72-ol-0-0-11809
  article-title: Altered expression of long non-coding RNAs during genotoxic stress-induced cell death in human glioma cells
  publication-title: J Neurooncol
  doi: 10.1007/s11060-015-1718-0
– volume: 12
  start-page: e0182305
  year: 2017
  ident: key20220302135148_b39-ol-0-0-11809
  article-title: An androgen reduced transcript of LncRNA GAS5 promoted prostate cancer proliferation
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0182305
– volume: 1832
  start-page: 1613
  year: 2013
  ident: key20220302135148_b35-ol-0-0-11809
  article-title: Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbadis.2013.05.005
– volume: 48
  start-page: 310
  year: 1997
  ident: key20220302135148_b20-ol-0-0-11809
  article-title: The growth arrest genes gas5, gas6, and CHOP-10 (gadd153) are expressed in the mouse preimplantation embryo
  publication-title: Mol Reprod Dev
  doi: 10.1002/(SICI)1098-2795(199711)48:3<310::AID-MRD2>3.0.CO;2-U
– volume: 65
  start-page: 1494
  year: 2016
  ident: key20220302135148_b4-ol-0-0-11809
  article-title: Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β catenin signalling pathway via suppression of activator protein 2α
  publication-title: Gut
  doi: 10.1136/gutjnl-2014-308392
– year: 2016
  ident: key20220302135148_b48-ol-0-0-11809
  article-title: Long non-coding RNA GAS5 acts as a molecular sponge to regulate miR-23a in gastric cancer
  publication-title: Minerva Med
– volume: 54
  start-page: E1
  year: 2015
  ident: key20220302135148_b61-ol-0-0-11809
  article-title: A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer
  publication-title: Mol Carcinog
  doi: 10.1002/mc.22120
– volume: 14
  start-page: 1867
  year: 2016
  ident: key20220302135148_b5-ol-0-0-11809
  article-title: A long non-coding RNA, lncLGR, regulates hepatic glucokinase expression and glycogen storage during fasting
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2016.01.062
– volume: 3
  start-page: 77
  year: 2015
  ident: key20220302135148_b6-ol-0-0-11809
  article-title: Computational approaches for the analysis of ncRNA through deep sequencing techniques
  publication-title: Front Bioeng Biotechnol
  doi: 10.3389/fbioe.2015.00077
– volume: 13
  start-page: 472
  year: 2018
  ident: key20220302135148_b77-ol-0-0-11809
  article-title: lncRNA GAS5 reverses EMT and tumor stem cell-mediated gemcitabine resistance and metastasis by targeting miR-221/SOCS3 in pancreatic cancer
  publication-title: Mol Ther Nucleic Acids
  doi: 10.1016/j.omtn.2018.09.026
– volume: 20
  start-page: 1018
  year: 2015
  ident: key20220302135148_b7-ol-0-0-11809
  article-title: Targeting human long noncoding transcripts by endoribonucleaseprepared sirnas
  publication-title: J Biomol Screen
  doi: 10.1177/1087057115583448
– volume: 151
  start-page: 345
  year: 2018
  ident: key20220302135148_b63-ol-0-0-11809
  article-title: Lowly-expressed lncRNA GAS5 facilitates progression of ovarian cancer through targeting miR-196-5p and thereby regulating HOXA5
  publication-title: Gynecol Oncol
  doi: 10.1016/j.ygyno.2018.08.032
– volume: 118
  start-page: 4772
  year: 2017
  ident: key20220302135148_b75-ol-0-0-11809
  article-title: Long non-coding RNA GAS5 suppresses cell growth and epithelial-mesenchymal transition in osteosarcoma by regulating the miR-221/ARHI pathway
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.26145
– volume: 20
  start-page: 1558
  year: 2013
  ident: key20220302135148_b33-ol-0-0-11809
  article-title: Negative regulation of lncRNA GAS5 by miR-21
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2013.110
– volume: 9
  start-page: 238
  year: 2018
  ident: key20220302135148_b79-ol-0-0-11809
  article-title: Long non-coding RNA GAS5 promotes bladder cancer cells apoptosis through inhibiting EZH2 transcription
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-018-0264-z
– volume: 27
  start-page: 1096
  year: 2017
  ident: key20220302135148_b66-ol-0-0-11809
  article-title: Long non-coding RNA GAS5, which acts as a tumor suppressor via microRNA 21, regulates cisplatin resistance expression in cervical cancer
  publication-title: Int J Gynecol Cancer
  doi: 10.1097/IGC.0000000000001028
– volume: 28
  start-page: 195
  year: 2009
  ident: key20220302135148_b16-ol-0-0-11809
  article-title: GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer
  publication-title: Oncogene
  doi: 10.1038/onc.2008.373
– volume: 61
  start-page: 69
  year: 2011
  ident: key20220302135148_b34-ol-0-0-11809
  article-title: Global cancer statistics
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.20107
– volume: 3
  start-page: ra8
  year: 2010
  ident: key20220302135148_b28-ol-0-0-11809
  article-title: Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor
  publication-title: Sci Signal
  doi: 10.1126/scisignal.2000568
– volume: 48
  start-page: 194
  year: 2018
  ident: key20220302135148_b31-ol-0-0-11809
  article-title: Effect of the lncRNA GAS5-miR-23a-ATG3 axis in regulating autophagy in patients with breast cancer
  publication-title: Cell Physiol Biochem
  doi: 10.1159/000491718
– volume: 7
  start-page: 27778
  year: 2016
  ident: key20220302135148_b32-ol-0-0-11809
  article-title: Downregulation of LncRNA GAS5 causes trastuzumab resistance in breast cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.8413
SSID ssj0000561886
Score 2.4977047
SecondaryResourceType review_article
Snippet Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation,...
SourceID pubmedcentral
proquest
gale
crossref
SourceType Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage 2587
SubjectTerms Androgens
Apoptosis
Bladder cancer
Bone cancer
Breast cancer
Cancer metastasis
Cancer research
Cancer therapies
Cell cycle
Cell division
Cell growth
Cervical cancer
Colorectal cancer
Digestive system cancer
Disease
Endometrial cancer
Esophageal cancer
Gastric cancer
Genes
Glioma
Gliomas
Kidney cancer
Lapatinib
Liver cancer
Lung cancer
Lymphatic system
Medical diagnosis
Medical prognosis
Melanoma
Metastasis
Mortality
Oncology
Ovarian cancer
Pancreatic cancer
Prostate cancer
Review
RNA
Sarcoma
Skin cancer
Squamous cell carcinoma
Stomach cancer
Thyroid cancer
Thyroid diseases
Tumors
Title Long non‑coding RNA GAS5 in human cancer (Review)
URI https://www.proquest.com/docview/2432391425
https://www.proquest.com/docview/2433240983
https://pubmed.ncbi.nlm.nih.gov/PMC7400976
Volume 20
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR3LbtQwcASthLggykMEShskBBywmjjeODmhbdVSIVihQqW9Wc7YKZWqpLTb_2fG8YamElxyiMdyMg_PjD0PgLfILax15gXngAiFGkWjMxQz8kZQW09aKERbLMrjU_VlOVvGA7frGFa53hPDRu165DPyPakKWdQ5sdiny9-Cu0bx7WpsoXEfNkPpMuJnvdTjGQtbx1Vo9khsJwXHHg5lNklLy72ebx4kbxoVhyPeUkt3N-e7AZO3NNDRY3gUTcd0PtB6C-757gk8-BYvx5_Ch699d5aSOy-wZ42Unizm6ef5j1l63qWhF1-KTOOrZ3B6dPjz4FjERggCVZ2thMbWYW2zRpZV6ZrCuaZtlSXhtDLDOnPkHtdSO1XmLclbjiib0irPLxxNLZ7DBq3uX0BatnbWyILQSHZEazPbVl5L39rKudypPIGPazwYjFXCuVnFhSFvgdFm-gvDaDMBbQm8G8Evh_IY_wLcZaSaIbtzFCszL4uCbEp6JPA-QLBg0YpoY34AfTeXqJpAbk8gSSBwOrwmnIkCeW3-sk8Cb8ZhnslBZp3vbwIMlyesqyIBPSH4-G9cjHs60p3_CkW5teKUmPLl_xd_BQ8ZJ0OQ2jZsrK5u_GuyalbNTmDdHdjcP1x8P_kDelj0og
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VrQRcEE8RKNRIvA5YTRxvnBwQWqBlS7crVFqpN9exnbZSlZR2K8Sf4jcykxdNJbj1kkM8iZPxZ8-MPQ-Al5ZKWKvQc4oB4dIqy3MVWj5Ga8Qq41EK1d4W82S6J7_uj_eX4HcXC0Nuld2aWC_UrrK0R74mZCziLEKIfTj9walqFJ2udiU0Glhs-V8_0WQ7f7_5Gcf3lRAb67ufprytKsCtzMIFV7ZwNjNhLpI0cXnsXF4U0iDSjQhtFjq0NTOhnEyiAsEbWSvyxEhPNxw-GuN7b8CypIjWESx_XJ9_2-l3dUgfT-vykgh0wcnbsUnsiXqBWKvorEPQMpWSA-QlQXhVHFx10bwk8zbuwp1WWWWTBl33YMmX9-Hmdnsc_wDezqrykJVVyW1FMpDtzCfsy-T7mB2XrK7-xyyh6uwh7F0Lkx7BCHv3j4ElhRnnIsaBQ82lMKEpUq-EL0zqXORkFMC7jg_atnnJqTzGiUb7hNimqxNNbNM12wJ43ZOfNgk5_kW4SkzVTTxpP5H1JIlj1GLxEsCbmoKmMvZoTRuRgN9NSbEGlCsDSpyCdtjcDZxul4Bz_RewAbzom-lJcmsrfXVR01BCxCyNA1CDAe__jdJ_D1vK46M6DbiSFISTPPl_56twa7q7PdOzzfnWU7hN_Glc5FZgtDi78M9Qp1rkz1sgMzi47rnzB6idM7Q
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIlVcEE8RKNRIvA5YmzjZODkgtKIsLS0rBFTam3H8gEpVUtqtEH-NX8eM86CpBLdecogncTL-xjO25wHwxFAJaxk7TjEgPDPS8ErGhk9xNWKkdqiFgrfFIt85yN4vp8s1-N3HwpBbZT8nhonaNob2yCciS0VaJgixie_cIj5uz18f_-BUQYpOWvtyGi1E9tyvn7h8O321u41j_VSI-dsvb3Z4V2GAm6yMV1wab02p40rkRW6r1NrK-0wj6rWITRlbXHeWQtosTzwCOTFGVLnOHN2w-GiK770CV2WKVhXKklzKYX-HLPMiFJpEyAtOfo9tik-0EMSkoVMPQRNWQa6Q51TiRcVw0VnznPab34DrndnKZi3ObsKaq2_BxofuYP42vNhv6m-sbmpuGtKG7NNixt7NPk_ZYc1CHUBmCF8nd-DgUlh0F9axd3cPWO71tBIpDiHaMF7H2hdOCud1YW1isySClz0flOkylFOhjCOFKxVim2qOFLFNBbZF8GwgP25Tc_yLcIuYqtrI0kGk1SxPU7Rn8RLB80BBQo09Gt3FJuB3U3qsEeXmiBKF0Yyb-4FT3WRwqv5CN4LHQzM9SQ5utWvOAg2lRiyLNAI5GvDh3ygR-LilPvweEoLLjMJx8vv_73wLNlBi1P7uYu8BXCP2tL5ym7C-OjlzD9G4WlWPAooZfL1ssfkDf7o2ew
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Long+non-coding+RNA+GAS5+in+human+cancer&rft.jtitle=Oncology+letters&rft.au=Yang%2C+Xiaoyan&rft.au=Xie%2C+Zhizhong&rft.au=Lei%2C+Xiaoyong&rft.au=Gan%2C+Runliang&rft.date=2020-09-01&rft.pub=Spandidos+Publications&rft.issn=1792-1074&rft.volume=20&rft.issue=3&rft.spage=2587&rft_id=info:doi/10.3892%2Fol.2020.11809&rft.externalDocID=A633565335
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1792-1074&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1792-1074&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1792-1074&client=summon