Long non‑coding RNA GAS5 in human cancer (Review)

Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth....

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Bibliographic Details
Published inOncology letters Vol. 20; no. 3; pp. 2587 - 2594
Main Authors Yang, Xiaoyan, Xie, Zhizhong, Lei, Xiaoyong, Gan, Runliang
Format Journal Article
LanguageEnglish
Published Athens Spandidos Publications 01.09.2020
Spandidos Publications UK Ltd
D.A. Spandidos
Subjects
Androgens
Apoptosis
Bladder cancer
Bone cancer
Breast cancer
Cancer metastasis
Cancer research
Cancer therapies
Cell cycle
Cell division
Cell growth
Cervical cancer
Colorectal cancer
Digestive system cancer
Disease
Endometrial cancer
Esophageal cancer
Gastric cancer
Genes
Glioma
Gliomas
Kidney cancer
Lapatinib
Liver cancer
Lung cancer
Lymphatic system
Medical diagnosis
Medical prognosis
Melanoma
Metastasis
Mortality
Oncology
Ovarian cancer
Pancreatic cancer
Prostate cancer
Review
RNA
Sarcoma
Skin cancer
Squamous cell carcinoma
Stomach cancer
Thyroid cancer
Thyroid diseases
Tumors
Online AccessGet full text
ISSN1792-1074
1792-1082
DOI10.3892/ol.2020.11809

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Summary:Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth. The present study focused on growth arrest-specific transcript 5 (GAS5), a well-known lncRNA that acts as a tumor suppressor but is suppressed in multiple types of cancer, including mammary carcinoma, prostate cancer, colorectal cancer, gastric cancer, melanoma, esophageal squamous cell carcinoma, lung cancer, ovarian cancer, cervical cancer, gliomas, osteosarcoma, pancreatic cancer, bladder cancer, kidney cancer, papillary thyroid carcinoma, neuroblastoma, endometrial cancer and liver cancer. Notably, GAS5 is overexpressed in liver cancer, potentially functioning as an oncogene. In the present study, the diagnostic and therapeutic roles of GAS5 in different tumors were reviewed, with a summary of the potential clinical application of the lncRNA, which may help identify novel study directions for GAS5. Key words: long non-coding RNA, GAS5, tumor suppressor gene, diagnostic biomarker, therapeutic targe
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ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2020.11809