Human nasal epithelial cells derived from multiple subjects exhibit differential responses to H3N2 influenza virus infection in vitro
[...]to elucidate the sequential and spatiotemporal reactions of pathogen sensors to respiratory viruses documented in different experimental models,9,E5,E13-E20 we performed analyses of (1) IAV receptors possessing terminal α-2,6-linked or α-2,3-linked sialic acid residues (α-2,6-SA or α-2,3-SA...
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| Published in | Journal of allergy and clinical immunology Vol. 138; no. 1; pp. 276 - 281.e15 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
01.07.2016
Elsevier Limited |
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| Abstract | [...]to elucidate the sequential and spatiotemporal reactions of pathogen sensors to respiratory viruses documented in different experimental models,9,E5,E13-E20 we performed analyses of (1) IAV receptors possessing terminal α-2,6-linked or α-2,3-linked sialic acid residues (α-2,6-SA or α-2,3-SA) and the rhinovirus receptor intercellular adhesion molecule 1; (2) the extracellular receptor Toll-like receptor (TLR) 4, the orphan human receptor TLR10, and the cytosolic receptors TLR3, TLR7, TLR8, and TLR9 located in the endosome; (3) the cytoplasmic sensors retinoic acid-inducible gene 1 (RIG-I) and NOD-like receptor family, pyrin domain containing 3; and (4) cytoplasmic molecules for sensing, including interferon regulatory factor (IRF) 3 and IRF7 and IFN-β promoter stimulator 1. |
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| AbstractList | [...]to elucidate the sequential and spatiotemporal reactions of pathogen sensors to respiratory viruses documented in different experimental models,9,E5,E13-E20 we performed analyses of (1) IAV receptors possessing terminal α-2,6-linked or α-2,3-linked sialic acid residues (α-2,6-SA or α-2,3-SA) and the rhinovirus receptor intercellular adhesion molecule 1; (2) the extracellular receptor Toll-like receptor (TLR) 4, the orphan human receptor TLR10, and the cytosolic receptors TLR3, TLR7, TLR8, and TLR9 located in the endosome; (3) the cytoplasmic sensors retinoic acid-inducible gene 1 (RIG-I) and NOD-like receptor family, pyrin domain containing 3; and (4) cytoplasmic molecules for sensing, including interferon regulatory factor (IRF) 3 and IRF7 and IFN-β promoter stimulator 1. |
| Author | Tan, Kai Sen Li, Chunwei Yan, Yan Tran, Thai Wang, De-Yun Chao, Siew Shuen Shi, Li Chow, Vincent T. Sugrue, Richard J. |
| Author_xml | – sequence: 1 givenname: Yan surname: Yan fullname: Yan, Yan organization: Department of Otolaryngology, National University of Singapore, Singapore – sequence: 2 givenname: Kai Sen surname: Tan fullname: Tan, Kai Sen organization: Department of Microbiology and Immunology, National University of Singapore, Singapore – sequence: 3 givenname: Chunwei surname: Li fullname: Li, Chunwei organization: Department of Otolaryngology, National University of Singapore, Singapore – sequence: 4 givenname: Thai surname: Tran fullname: Tran, Thai organization: Department of Physiology, National University of Singapore, Singapore – sequence: 5 givenname: Siew Shuen surname: Chao fullname: Chao, Siew Shuen organization: Department of Otolaryngology, National University of Singapore, Singapore – sequence: 6 givenname: Richard J. surname: Sugrue fullname: Sugrue, Richard J. organization: School of Biological Sciences, Nanyang Technological University, Singapore – sequence: 7 givenname: Li surname: Shi fullname: Shi, Li organization: Department of Otolaryngology, Qilu Hospital, Shandong University, Shandong, China – sequence: 8 givenname: Vincent T. surname: Chow fullname: Chow, Vincent T. email: vincent_chow@nuhs.edu.sg organization: Department of Microbiology and Immunology, National University of Singapore, Singapore – sequence: 9 givenname: De-Yun surname: Wang fullname: Wang, De-Yun email: entwdy@nus.edu.sg organization: Department of Otolaryngology, National University of Singapore, Singapore |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26806046$$D View this record in MEDLINE/PubMed |
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| Title | Human nasal epithelial cells derived from multiple subjects exhibit differential responses to H3N2 influenza virus infection in vitro |
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