Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People

To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 10 ) over time among cognitively normal older people. We examined the cross-sectional and longitudinal associations of OA with HpVR among individuals with norma...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in aging neuroscience Vol. 12; p. 190
Main Authors Li, Xiang, Tong, Qiaowen, Gao, Jianqing, Liu, Cailong, Liu, Yangbo
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 14.08.2020
Frontiers Media S.A
Subjects
Age
Aging
Alzheimer's disease
Arthritis
Cognition
Cognition & reasoning
Cognitive ability
Dementia
Demographics
Gender
Genotypes
hippocampal volumes
Hippocampus
Longitudinal studies
longitudinal study
Medical imaging
Memory
Neurodegenerative diseases
Neuroimaging
Neuroscience
Neurosciences
normal cognition
Older people
Osteoarthritis
Variables
hippocampal volumes
longitudinal study
Alzheimer’s disease
normal cognition
osteoarthritis
Online AccessGet full text

Cover

More Information
Summary:To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 10 ) over time among cognitively normal older people. We examined the cross-sectional and longitudinal associations of OA with HpVR among individuals with normal cognition (NC) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. At baseline, a total of 372 individuals with NC were included. In the cross-sectional analyses of baseline data, we did not find a significant relationship between OA and HpVR among individuals with NC. However, in the longitudinal analyses, OA was significantly associated with change in HpVR over time among individuals with NC. Specifically, compared with individuals without OA, those with OA showed a faster decline in HpVR over time when controlling for other potential confounders, including age, educational attainment, gender, and APOE4 genotype. OA status was significantly associated with a change in HpVR over time among individuals with NC.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Reviewed by: Kewei Chen, Banner Alzheimer’s Institute, United States; Wen-Cheng Xiong, Case Western Reserve University, United States; Ana Capuano, Rush University, United States
Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf
Edited by: Gjumrakch Aliev, GALLY International Biomedical Research & Consulting LLC, United States
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2020.00190