The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity

• Published in: Basic and clinical neuroscience Vol. 12; no. 5; pp. 667 - 674
• Main Authors: Oshnokhah, Mahin, Bagheri, Maryam, Ghaneialvar, Hori, Haghani, Karimeh, Khorshidi, Ali, Shahbazi, Ali, Salari, Sajjad
• Format: Journal Article
• Language: English
• Published: Iran Negah Scientific Publisher 01.09.2021; Iranian Neuroscience Society; Iran University of Medical Sciences
• Subjects: Antioxidants; mda; Mental disorders; Nitric oxide; Oxidants; Oxidation; Oxidative stress; Research Paper; Serum levels; sod; Suicide; suicide behavior; Suicides & suicide attempts; tac; Oxidative stress; SOD; Suicide behavior; MDA; TAC
• ISSN: 2008-126X; 2228-7442
• DOI: 10.32598/bcn.2021.1917.1

Oxidative stress plays a critical role in the pathogenesis of neurodegenerative and neuropsychiatric disorders. However, its role in suicidal behavior has not been clarified yet. Consequently, we aimed to evaluate the oxidant-antioxidant status in the serum of suicide attempters in Ilam city. Fifty suicide attempters and 40 control subjects (volunteers) aged 18-35 years were studied in the current experiment. To consider the oxidant-antioxidant status, serum levels of Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide Dismutase (SOD), and the Total Antioxidant Capacity (TAC) were measured. Serum levels of SOD and TAC were significantly lower in the suicide attempters group compared to the controls. Furthermore, serum NO level was significantly higher in the suicide attempters compared to the control groups. Interestingly, the serum level of MDA was significantly lower in the suicide attempters compared to the control groups. The oxidative stress without MDA elevation, detected in suicide attempters, can be considered a biochemical hallmark in suicide behavior.