Opportunities and Challenges in Antiparasitic Drug Discovery

New antiparasitic drugs are urgently needed to treat and control diseases such as malaria, leishmaniasis, sleeping sickness and filariasis, which affect millions of people each year. However, because the majority of those infected live in countries in which the prospects of any financial return on i...

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Published inNature reviews. Drug discovery Vol. 4; no. 9; pp. 727 - 740
Main Authors Bendig, Mary, Pink, Richard, Hudson, Alan, Mouriès, Marie-Annick
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.09.2005
Subjects
Animals
Antiparasitic Agents - chemistry
Antiparasitic Agents - pharmacology
Antiparasitic Agents - therapeutic use
Drug Design
Technology, Pharmaceutical - methods
Technology, Pharmaceutical - trends
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Summary:New antiparasitic drugs are urgently needed to treat and control diseases such as malaria, leishmaniasis, sleeping sickness and filariasis, which affect millions of people each year. However, because the majority of those infected live in countries in which the prospects of any financial return on investment are too low to support market-driven drug discovery and development, alternative approaches are needed. In this article, challenges and opportunities for antiparasitic drug discovery are considered, highlighting some of the progress that has been made in recent years, partly through scientific advances, but also by more effective partnership between the public and private sectors.
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ISSN:1474-1776
1474-1784
1474-1784
DOI:10.1038/nrd1824