Evolution of lymphoid tissues

Lymphoid organs are integral parts of all vertebrate adaptive immune systems. Primary lymphoid tissues exhibit a remarkable functional dichotomy: T cells develop in specialized thymopoietic tissues located in the pharynx, whereas B cells develop in distinct areas of general hematopoietic areas, such...

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Bibliographic Details
Published inTrends in immunology Vol. 33; no. 6; pp. 315 - 321
Main Authors Boehm, Thomas, Hess, Isabell, Swann, Jeremy B
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2012
Elsevier Limited
Subjects
Adaptive Immunity
Allergy and Immunology
Animals
Biological Evolution
birds
Bone marrow
Cell Differentiation
correlation
Humans
Immune system
kidneys
lymph nodes
Lymphocytes
Lymphoid Tissue - cytology
Lymphoid Tissue - immunology
mammals
pharynx
Rodents
spleen
T cell receptors
T-lymphocytes
T-Lymphocytes - cytology
T-Lymphocytes - immunology
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Summary:Lymphoid organs are integral parts of all vertebrate adaptive immune systems. Primary lymphoid tissues exhibit a remarkable functional dichotomy: T cells develop in specialized thymopoietic tissues located in the pharynx, whereas B cells develop in distinct areas of general hematopoietic areas, such as the kidney or bone marrow. Among secondary lymphoid tissues, the spleen is present in all vertebrates, whereas lymph nodes represent an innovation particular to mammals and some birds. A comparative analysis of anatomical, functional and genomic features thus reveals the core components of adaptive immune systems. Such information has guided recent attempts at reconstructing lymphopoietic functions in vivo and in the future might inspire the development of new strategies for medical interventions restoring and modulating immune functions.
Bibliography:http://dx.doi.org/10.1016/j.it.2012.02.005
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ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2012.02.005