Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG

This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous ch...

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Published inFrontiers in neuroscience Vol. 13; p. 851
Main Authors Cai, Yuexin, Li, Jiahong, Chen, Yanhong, Chen, Wan, Dang, Caiping, Zhao, Fei, Li, Wenrui, Chen, Guisheng, Chen, Suijun, Liang, Maojin, Zheng, Yiqing
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 14.08.2019
Frontiers Media S.A
Subjects
Brain research
Ears & hearing
EEG
Electroencephalography
Frontal lobe
functional connectivity
Hearing loss
Insomnia
ISSNHL
Localization
Neural networks
Neuroscience
Neurosciences
source localization
Studies
Synchronization
Temporal gyrus
Tinnitus
China
source localization
ISSNHL
functional connectivity
tinnitus
EEG
Online AccessGet full text
ISSN1662-453X
1662-4548
1662-453X
DOI10.3389/fnins.2019.00851

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Summary:This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous changes in 25 ISSNHL subjects and 27 healthy controls. ISSNHL subjects had significantly reduced activity in the left frontal lobe at the alpha 2 frequency band compared with controls. Linear lagged connectivity and lagged coherence analysis showed significantly reduced functional connectivity between the temporal gyrus and supramarginal gyrus at the gamma 2 frequency band in the ISSNHL group. Additionally, a significantly reduced functional connectivity was found between the central cingulate gyrus and frontal lobe under lagged phase synchronization analysis. These results strongly indicate inhibition of brain area activity and change in functional connectivity in ISSNHL with tinnitus patients.
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Edited by: Zhenchang Wang, Beijing Friendship Hospital, Capital Medical University, China
Reviewed by: Junpeng Zhang, Sichuan University, China; Vijaya Prakash Muthaiah, University at Buffalo, United States
This article was submitted to Auditory Cognitive Neuroscience, a section of the journal Frontiers in Neuroscience
These authors have contributed equally to this work
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2019.00851