The Possible Role of Hepatitis A Virus in the Pathogenesis of Atherosclerosis

• Published in: The Journal of infectious diseases Vol. 182; no. 6; pp. 1583 - 1587
• Main Authors: Zhu, Jianhui, Quyyumi, Arshed A., Norman, James E., Costello, Rene, Csako, Gyorgy, Epstein, Stephen E.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.12.2000; University of Chicago Press; Oxford University Press
• Subjects: Adult; Aged; Aged, 80 and over; Antibodies; Atherosclerosis; Biological and medical sciences; C-Reactive Protein - analysis; Chlamydia pneumoniae; Computer aided design; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - etiology; Coronary Artery Disease - virology; Cytomegalovirus; Diabetes; Female; Helicobacter pylori; Hepatitis A - blood; Hepatitis A - complications; Hepatitis A virus; Hepatitis A Virus, Human; Hepatitis Antibodies - blood; Herpes simplex virus 1; Human viral diseases; Humans; Hypertension; Immunoglobulin G - blood; Infections; Infectious diseases; Major Articles; Male; Medical sciences; Middle Aged; Odds Ratio; Pathogens; Predisposing factors; Risk Factors; Seroepidemiologic Studies; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral hepatitis; Vascular disease; Virus; Hepatitis A virus; Picornaviridae; Pathogenesis; Atherosclerosis; Cardiovascular disease; Hepatovirus
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/317613

The possible association between hepatitis A virus (HAV) infection and coronary artery disease (CAD) was studied. Blood from 391 patients undergoing coronary angiography was tested for serum IgG antibodies to HAV and C-reactive protein (CRP). Of the 391 patients, 205 (52%) had anti-HAV IgG antibodies. CAD prevalence was 74% in HAV-seropositive and 52% in HAV-seronegative patients (P < .0001); significance persisted after adjustment for either traditional CAD risk factors or for risk factors plus other infectious agents (cytomegalovirus, Chlamydia pneumoniae, Helicobacterpylori, and herpes simplex virus). In addition, CRP levels were significantly higher in HAV-seropositive than in HAV-seronegative patients (P = .013) in both univariate and multivariate analyses. Logistic regression analysis demonstrated that HAV seropositivity is an independent predictor of risk for CAD and elevated CRP levels. HAV infection is therefore associated with CAD, which raises the possibility that this virus may play a causal role in atherogenesis.