Differential Roles of Vascular Endothelial Growth Factor Receptor-1 and Receptor-2 in Angiogenesis

• Published in: BMB reports Vol. 39; no. 5; pp. 469 - 478
• Main Author: Shibuya, Masabumi (University of Tokyo, Tokyo, Japan), E-mail: shibuya@ims.u-tokyo.ac.jp
• Format: Journal Article
• Language: English
• Published: Korea (South) 30.09.2006
• Subjects: Agiogenesis; Animals; Atherosclerosis - physiopathology; Embryonic Development - physiology; Female; Humans; Inflammation - physiopathology; MACROFAGOS; MACROPHAGE; MACROPHAGES; Neoplasm Metastasis - physiopathology; Neoplasms - blood supply; Neoplasms - physiopathology; Neovascularization, Pathologic; Neovascularization, Physiologic; Pre-Eclampsia - physiopathology; Pregnancy; Signal Transduction; Tyrosine kinase receptor; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Vascular Endothelial Growth Factor Receptor-1 - chemistry; Vascular Endothelial Growth Factor Receptor-1 - genetics; Vascular Endothelial Growth Factor Receptor-1 - physiology; Vascular Endothelial Growth Factor Receptor-2 - chemistry; Vascular Endothelial Growth Factor Receptor-2 - genetics; Vascular Endothelial Growth Factor Receptor-2 - physiology; VEGF-E; VEGFR1; VEGFR2; Viral Proteins - metabolism
• ISSN: 1225-8687; 1976-6696; 0219-1024
• DOI: 10.5483/bmbrep.2006.39.5.469

Vascular endothelial growth factor (VEGF)-A, a major regulator for angiogenesis, binds and activates two tyrosine kinase receptors, VEGFR1 (Flt-1) and VEGFR2 (KDR/Flk-1). These receptors regulate physiological as well as pathological angiogenesis. VEGFR2 has strong tyrosine kinase activity, and transduces the major signals for angiogenesis. However, unlike other representative tyrosine kinase receptors which use the Ras pathway, VEGFR2 mostly uses the Phospholipase-Cγ-Protein kinase-C pathway to activate MAP-kinase and DNA synthesis.