A comparison of the oxidative stress response in single-incision laparoscopic versus multi-trocar laparoscopic totally extraperitoneal inguinal hernia repair

• Published in: Wideochirurgia i inne techniki mało inwazyjne Vol. 15; no. 4; pp. 567 - 573
• Main Authors: Białecki, Jacek T, Myszka, Waldemar, Wysocka, Ewa, Sowier, Sebastian, Pyda, Przemysław, Antkowiak, Ryszard, Antkowiak, Łukasz, Sowier, Anna, Krasiński, Zbigniew
• Format: Journal Article
• Language: English
• Published: Poland Termedia Publishing House 24.02.2020
• Subjects: Hernias; inguinal hernia repair; Laparoscopy; minimally invasive surgery; Original Paper; Oxidative stress; single-incision laparoscopic surgery; Surgery; inguinal hernia repair; minimally invasive surgery; oxidative stress; single-incision laparoscopic surgery
• ISSN: 1895-4588; 2299-0054; 2299-0054
• DOI: 10.5114/WIITM.2020.93202

Surgical treatment is always associated with tissue damage and the subsequent development of oxidative stress. To compare the oxidative stress response in patients treated operatively for inguinal hernia with multi-trocar laparoscopic totally extraperitoneal technique (TEP) or single-incision laparoscopic totally extraperitoneal technique (TEP-SI). A randomized group of 34 patients with one-sided inguinal hernia was enrolled in the study. Seventeen patients were treated with a standard TEP method (group 1) and the other 17 patients were treated with the TEP-SI technique (group 2). Thiobarbituric acid reactive substances (TBARS) and total antioxidant status (TAS) as the oxidative stress markers were measured before surgery (0), 1 day (1) and 4 days (2) after surgery. A decrease in TAS on the first day after surgery was observed in both groups. Sustained reduction on the fourth day after surgery was observed in group 1, whereas in group 2 an increase followed. A statistically significant difference was observed in TAS (2 : 0) ratio with a meaningful decrease in group 1. TBARS concentration was elevated 1 day after surgery in both groups. It remained at an elevated level on the fourth day after surgery in group 1, while it decreased in group 2. The duration of surgery was higher in group 2 (mean: 57.5 min) than in group 1 (mean: 50.0 min) (p = 0.0286). Oxidative stress levels are lower in patients treated operatively by TEP-SI technique than by TEP. TEP-SI may be considered as a less invasive technique associated with less tissue injury.