Cholesterol Sulfate and Cholesterol Sulfotransferase Inhibit Gluconeogenesis by Targeting Hepatocyte Nuclear Factor 4α

• Published in: Molecular and Cellular Biology Vol. 34; no. 3; pp. 485 - 497
• Main Authors: Shi, Xiongjie, Cheng, Qiuqiong, Xu, Leyuan, Yan, Jiong, Jiang, Mengxi, He, Jinhan, Xu, Meishu, Stefanovic-Racic, Maja, Sipula, Ian, O'Doherty, Robert Martin, Ren, Shunlin, Xie, Wen
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.02.2014; Taylor & Francis
• Subjects: acetyl coenzyme A; acetylation; Acetylation - drug effects; Animals; biochemical pathways; Blotting, Western; byproducts; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; cell biology; Cell Line, Tumor; Cell Nucleus - drug effects; Cell Nucleus - metabolism; Cells, Cultured; cholesterol; Cholesterol Esters - metabolism; Cholesterol Esters - pharmacology; Coenzyme A Ligases - genetics; Coenzyme A Ligases - metabolism; Colforsin - pharmacology; Diet, High-Fat - adverse effects; enzymes; Gene Expression - drug effects; genetically modified organisms; gluconeogenesis; Gluconeogenesis - drug effects; Gluconeogenesis - genetics; glucose; Glucose - metabolism; Hepatocyte Nuclear Factor 4 - genetics; Hepatocyte Nuclear Factor 4 - metabolism; homeostasis; Humans; Insulin Resistance; leptin; liver; Mice; Mice, Inbred C57BL; Mice, Obese; Mice, Transgenic; obesity; Obesity - etiology; Obesity - genetics; Obesity - metabolism; Reverse Transcriptase Polymerase Chain Reaction; sulfates; Sulfotransferases - genetics; Sulfotransferases - metabolism; therapeutics
• ISSN: 0270-7306; 1098-5549; 1098-5549
• DOI: 10.1128/MCB.01094-13

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