Long Non-coding RNA TUSC7, a Target of miR-23b, Plays Tumor-Suppressing Roles in Human Gliomas

( ) is a novel tumor suppressor gene generating long non-coding RNA (lncRNAs) in several types of human cancers. The expression and function of in human brain glioma has yet to be elucidated. In this study, was poorly expressed in tissues and cell lines of glioma, and the lower expression was correl...

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Published inFrontiers in cellular neuroscience Vol. 10; p. 235
Main Authors Shang, Chao, Guo, Yan, Hong, Yang, Xue, Yi-xue
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 06.10.2016
Frontiers Media S.A
Subjects
Apoptosis
Autophagy
Bioinformatics
Brain cancer
Cancer therapies
Cell cycle
Cell growth
Cell migration
Cell proliferation
Chemotherapy
Gastric cancer
Genes
Glioma cells
Laboratories
Liver cancer
Medical ethics
Medical prognosis
Metastasis
Neuroscience
Neurosciences
Non-coding RNA
Radiation therapy
Surgery
Tumor suppressor genes
Tumors
United States > US
China
TUSC7
glioma
noncoding RNA
tumor suppress gene
mir-23b
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Summary:( ) is a novel tumor suppressor gene generating long non-coding RNA (lncRNAs) in several types of human cancers. The expression and function of in human brain glioma has yet to be elucidated. In this study, was poorly expressed in tissues and cell lines of glioma, and the lower expression was correlated with glioma of the worse histological grade. Moreover, TUSC7 is a prognostic biomarker of glioma patients. Up-regulation of suppressed cellular proliferation and invasion of glioma cells, and accelerated cellular apoptosis. Bioinformatics analysis showed that TUSC7 specifically binds to miR-23b. MiR-23b was up-regulated in glioma and negatively correlated with the expression of TUSC7. The miR-23b expression was inhibited remarkably by the upregulation of TUSC7 and the reciprocal inhibition was determined between TUSC7 and miR-23b.RNA pull-down and luciferase reporter assays were used to validate the sequence-specific correlation between miR-23b and TUSC7. TUSC7 inhibited the proliferation, migration and invasion of glioma cells and promoted cellular apoptosis largely bypassing miR-23b. We conclude that the lncRNA TUSC7 acted as a tumor suppressor gene negatively regulated by miR-23b, suggesting a novel therapeutic strategy against gliomas.
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Reviewed by: Vishwajeet Amatya, Hiroshima University, Japan; Cristiana Tanase, “Victor Babes" National Institute of Pathology, Romania
Edited by: James Francis Curtin, Dublin Institute of Technology, Ireland
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2016.00235