COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study

COVID-19 vaccines have achieved a significant reduction in mortality, yet objective estimates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to Septem...

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Published inVaccines (Basel) Vol. 10; no. 5; p. 812
Main Authors Valladares-Garrido, Mario J, Zeña-Ñañez, Sandra, Peralta, C Ichiro, Puicón-Suárez, Jacqueline B, Díaz-Vélez, Cristian, Failoc-Rojas, Virgilio E
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.05.2022
MDPI
Subjects
Antigens
Cohort analysis
Coronaviruses
COVID-19
COVID-19 vaccines
Disease prevention
Drug dosages
Dyspnea
Epidemiology
Health surveillance
Hospitalization
Hospitals
Hypertension
Immunization
Medical prognosis
Mortality
Patients
Performance evaluation
Peru
Public health
Regression analysis
Regression models
Serology
Severe acute respiratory syndrome coronavirus 2
vaccination
vaccine effectiveness
Vaccine efficacy
Vaccines
Variables
Weighting methods
Peru
COVID-19
vaccine effectiveness
mortality
Peru
vaccination
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Summary:COVID-19 vaccines have achieved a significant reduction in mortality, yet objective estimates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to September 2021. We included hospitalized patients with COVID-19, whose data were stored in NotiWeb, a patient data system of the Peruvian Ministry of Health. We applied a propensity score-weighting method according to baseline characteristics of patients, and estimated hazard ratios (HR) using Cox regression models. Of 1553 participants, the average age was 55 years (SD: 16.8), 907 (58%) were male, and 592 (38%) deceased at 28-day follow-up. Before hospital admission, 74 (4.8%) had been immunized with at least one vaccine dose. Effectiveness against death in vaccinated patients was 50% at 90-day follow-up (weighted HR 0.50, 95% CI 0.28-0.89). Our results support the effectiveness of COVID-19 vaccination against death and provide information after early immunization in Peru.
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ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines10050812