TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)

• Published in: Immunity (Cambridge, Mass.) Vol. 6; no. 1; pp. 79 - 88
• Main Authors: Bodmer, Jean-Luc, Burns, Kim, Schneider, Pascal, Hofmann, Kay, Steiner, Véronique, Thome, Margot, Bornand, Thierry, Hahne, Michael, Schröter, Michael, Becker, Karin, Wilson, Anne, French, Lars E., Browning, Jeffrey L., MacDonald, H.Robson, Tschopp, Jürg
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 1997
• Subjects: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins - metabolism; Chromosomes, Human, Pair 1; Cytoplasm - chemistry; Fas Ligand Protein; Fas-Associated Death Domain Protein; Gene Expression; Humans; Ligands; Lymphocytes - physiology; Membrane Glycoproteins - metabolism; Molecular Sequence Data; Multigene Family; NF-kappa B - physiology; Receptors, Cell Surface - physiology; Receptors, Tumor Necrosis Factor - genetics; Receptors, Tumor Necrosis Factor - physiology; Receptors, Tumor Necrosis Factor, Member 25; RNA, Messenger - genetics; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 1074-7613; 1097-4180
• DOI: 10.1016/S1074-7613(00)80244-7

A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified. The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor 1. TRAMP is abundantly expressed on thymocytes and lymphocytes. Its extracellular domain is composed of four cysteine-rich domains, and the cytoplasmic region contains a death domain known to signal apoptosis. Overexpression of TRAMP leads to two major responses, NF-κB activation and apoptosis. TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2. In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family.