Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development

• Published in: Cell death & disease Vol. 2; no. 11; p. e226
• Main Authors: Cesca, F, Yabe, A, Spencer-Dene, B, Arrigoni, A, Al-Qatari, M, Henderson, D, Phillips, H, Koltzenburg, M, Benfenati, F, Schiavo, G
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2011; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/378/2571; 631/443/592/2726; 631/80/82/23; Animals; Antibodies; Biochemistry; Biomedical and Life Sciences; Cardiovascular System - cytology; Cardiovascular System - growth & development; Cardiovascular System - metabolism; Cell Biology; Cell Culture; Cell Death - physiology; Central Nervous System - cytology; Central Nervous System - growth & development; Central Nervous System - metabolism; Immunohistochemistry; Immunology; Life Sciences; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Mice; Mice, Transgenic; Original; original-article; Kidins220/ARMS; heart development; sensory ganglia; neuronal death
• ISSN: 2041-4889; 2041-4889
• DOI: 10.1038/cddis.2011.108

The growth factor family of neurotrophins has major roles both inside and outside the nervous system. Here, we report a detailed histological analysis of key phenotypes generated by the ablation of the Ki nase D in teracting s ubstrate of 220  kDa/ A nkyrin repeat- r ich m embrane s panning (Kidins220/ARMS) protein, a membrane-anchored scaffold for the neurotrophin receptors Trk and p75 NTR . Kidins220 is important for heart development, as shown by the severe defects in the outflow tract and ventricle wall formation displayed by the Kidins220 mutant mice. Kidins220 is also important for peripheral nervous system development, as the loss of Kidins220 in vivo caused extensive apoptosis of DRGs and other sensory ganglia. Moreover, the neuronal-specific deletion of this protein leads to early postnatal death, showing that Kidins220 also has a critical function in the postnatal brain.