Increased Activation of Default Mode Network in Early Parkinson's With Excessive Daytime Sleepiness

• Published in: Frontiers in neuroscience Vol. 13; p. 1334
• Main Authors: Ooi, Leon Qi Rong, Wen, Ming-Ching, Ng, Samuel Yong-Ern, Chia, Nicole Shuang-Yu, Chew, Isabel Hui Min, Lee, Weiling, Xu, Zheyu, Hartono, Septian, Tan, Eng King, Chan, Ling Ling, Tan, Louis Chew-Seng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 12.12.2019; Frontiers Media S.A
• Subjects: Apathy; Basal ganglia; Daytime; excessive daytime sleepiness; Functional magnetic resonance imaging; Geriatrics; independent component analyses; Medical screening; Movement disorders; neural network; Neural networks; Neurodegenerative diseases; Neurological disorders; Neuroscience; NMR; Nuclear magnetic resonance; Parkinson's disease; Prefrontal cortex; Quality of life; resting state fMRI; Sleep; Sleep and wakefulness; Singapore; excessive daytime sleepiness; resting state fMRI; neural network; Parkinson’s disease; independent component analyses
• ISSN: 1662-4548; 1662-453X; 1662-453X
• DOI: 10.3389/fnins.2019.01334

The underlying neuropathology of excessive daytime sleepiness (EDS) remains elusive in Parkinson's disease (PD). We aim to investigate neural network changes that underlie EDS in PD. Early PD patients comprising eighty-one patients without EDS (EDS-) and seventeen patients with EDS (EDS+) received a resting state functional MRI scan and the Epworth Sleepiness Scale (ESS). Connectivities within the default mode network (DMN), motor and basal ganglia networks were compared between the EDS+ and EDS- groups. Correlations between network connectivity and the severity of EDS were investigated through linear regression. EDS+ patients displayed a trend of increased network connectivity of the posterior DMN (pDMN). A significant positive correlation was found between connectivity of the ventromedial prefrontal cortex in the pDMN and ESS. EDS+ patients are likely to display increased activation in the DMN, suggesting neural compensation in early PD or impaired attentiveness due to mechanisms such as mind-wandering.