Ferroptosis and Brain Injury

Ferroptosis is a nonapoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid reactive oxygen species. Small-molecule screening and subsequent optimization have yielded potent and specific activators and inhibitors of this process. These compounds have been employe...

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Bibliographic Details
Published inDevelopmental neuroscience Vol. 40; no. 5-6; p. 382
Main Authors Magtanong, Leslie, Dixon, Scott J
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.2018
Subjects
Stroke
GPX4
Polyunsaturated fatty acids
Iron
Ischemia-repurfusion injury
PUFAs
Glutathione
Necrosis
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Summary:Ferroptosis is a nonapoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid reactive oxygen species. Small-molecule screening and subsequent optimization have yielded potent and specific activators and inhibitors of this process. These compounds have been employed to dissect the lethal mechanism and implicate this process in pathological cell death events observed in many tissues, including the brain. Indeed, ferroptosis is emerging as an important mechanism of cell death during stroke, intracerebral hemorrhage, and other acute brain injuries, and may also play a role in certain degenerative brain disorders. Outstanding issues include the practical need to identify molecular markers of ferroptosis that can be used to detect and study this process in vivo, and the more basic problem of understanding the relationship between ferroptosis and other forms of cell death that can be triggered in the brain during injury.
ISSN:1421-9859
DOI:10.1159/000496922