Antitumor Effects of L6, an IgG2a Antibody that Reacts with Most Human Carcinomas

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 83; no. 18; pp. 7059 - 7063
• Main Authors: Hellström, Ingegerd, Beaumier, Paul L., Hellström, Karl Erik
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 01.09.1986; National Acad Sciences
• Subjects: Animals; Antibodies; Antibodies, immunoglobulins; Antibodies, Monoclonal - immunology; Antibodies, Neoplasm - immunology; Antibody dependent cell cytotoxicity; Antigens; Antigens, Neoplasm - analysis; Biological and medical sciences; Complement System Proteins - immunology; Cytotoxicity; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunoglobulin G - immunology; Lungs; Lymphocytes; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular immunology; Monoclonal antibodies; Neoplasms - immunology; Non small cell lung carcinoma; Squamous cell carcinoma; Tumors; Antineoplastic agent; Human; Carcinoma; Rodentia; Cytotoxicity; Monoclonal antibody; IgG2; Antigen; Vertebrata; Mammalia; Mouse; Animal; Tumor
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.83.18.7059

Mouse monoclonal antibody L6 (IgG2a sub-type) recognizes a ganglioside antigen expressed at the surface of cells from human non-small-cell lung carcinomas, breast carcinomas, and colon carcinomas. We now show that this antibody can lyse L6 antigen-positive human tumor cells in the presence of Leu-11b-positive human lymphocytes (i.e., mediate antibody-dependent cellular cytotoxicity) or human serum (mediate complement-dependent cytotoxicity) and that it can inhibit the outgrowth of an L6 antigen-positive human tumor transplanted onto nude mice.