Cleaning Up: ER-Associated Degradation to the Rescue

All cellular proteins are subject to quality control “decisions,” which help to prevent or delay a myriad of diseases. Quality control within the secretory pathway creates a special challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for proteasomal degradation. This pro...

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Bibliographic Details
Published inCell Vol. 151; no. 6; pp. 1163 - 1167
Main Author Brodsky, Jeffrey L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 07.12.2012
Subjects
Animals
degradation
endoplasmic reticulum
Endoplasmic Reticulum - physiology
Endoplasmic Reticulum-Associated Degradation
Humans
polypeptides
Protein Folding
Protein Transport
proteins
Proteins - metabolism
quality control
Secretory Pathway
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Summary:All cellular proteins are subject to quality control “decisions,” which help to prevent or delay a myriad of diseases. Quality control within the secretory pathway creates a special challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for proteasomal degradation. This process is termed endoplasmic-reticulum (ER)-associated degradation (ERAD).
Bibliography:http://dx.doi.org/10.1016/j.cell.2012.11.012
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2012.11.012