The microbiome-adipose tissue axis in systemic metabolism

The intestinal commensal microbiome is an important component of host health, in part by contributing an abundance of metabolites that gain access to the systemic circulation. The microbiome thereby influences the physiology of numerous organ systems outside the gastrointestinal tract. The consequen...

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Published inAmerican journal of physiology: Gastrointestinal and liver physiology Vol. 318; no. 4; pp. G717 - G724
Main Authors Lundgren, Patrick, Thaiss, Christoph A.
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.04.2020
SeriesMicrobiome and Host Interactions
Subjects
Adipose tissue
Adipose Tissue - physiology
Colonization
Energy Metabolism - physiology
Gastrointestinal Microbiome - physiology
Gastrointestinal tract
Humans
Intestinal microflora
Intestine
Metabolism
Metabolites
Microbiomes
Remote control
Theme
Therapeutic applications
adipose tissue
metabolism
metabolites
microbiome
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Summary:The intestinal commensal microbiome is an important component of host health, in part by contributing an abundance of metabolites that gain access to the systemic circulation. The microbiome thereby influences the physiology of numerous organ systems outside the gastrointestinal tract. The consequences of this signaling axis between the intestinal microbiome and host are profound, in particular for the modulation of organismal metabolism. Here, we review recent examples whereby the intestinal microbiome influences host metabolism by influencing the biology of adipose tissue. We place a special emphasis on metabolite-driven pathways by which adipose tissue responds to alterations in intestinal microbial colonization. Given its accessibility for therapeutic interventions, the gut microbiome is an attractive relay module for the remote control of systemic metabolism.
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ISSN:0193-1857
1522-1547
1522-1547
DOI:10.1152/ajpgi.00304.2019