Hsa_circ_0008225 inhibits tumorigenesis of glioma via sponging miR-890 and promoting ZMYND11 expression

• Published in: Journal of pharmacological sciences Vol. 143; no. 2; pp. 74 - 82
• Main Authors: Wang, Xiaoliang, Feng, Hongru, Dong, Wei, Wang, Feng, Zhang, Gengshen, Wu, Jianliang
• Format: Journal Article
• Language: English
• Published: Japan Elsevier B.V 01.06.2020; Elsevier
• Subjects: Glioma; hsa_circ_0008225; microRNA-890; Tumorigenesis; ZMYND11; Tumorigenesis; Glioma; ZMYND11; microRNA-890; hsa_circ_0008225
• ISSN: 1347-8613; 1347-8648
• DOI: 10.1016/j.jphs.2020.02.008

Circular RNAs (circRNAs) play an important role in the tumorigenesis of glioma. Our study indicated that low hsa_circ_0008225 expression was associated with poor overall survival in patients with glioma. However, the relevant mechanism of hsa_circ_0008225 in glioma tumorigenesis remains unclear. Two datasets (GSE86202 and GSE92322) were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed circRNAs (DEcircRNAs) between glioma tissues and matched normal tissues were screened using R language. A total of 79 overlapping DEcircRNAs were identified by comparison of glioma and matched normal tissues. In addition, low hsa_circ_0008225 expression was associated with poor overall survival in patients with glioma. Overexpression of hsa_circ_0008225 markedly inhibited the proliferation, migration and invasion of SHG44 cells via inducing apoptosis. Mechanically, overexpression of hsa_circ_0008225 increased the expression of miR-890 targeted gene ZMYND11 via acting as a competitive ‘sponge’ of miR-890. Our results suggested that hsa_circ_0008225 functions as a tumor inhibitor in glioma by sponging miR-890 and then promoting the function of ZMYND11. Therefore, hsa_circ_0008225 could be a potential prognostic biomarker for the treatment of glioma.