A Cell Atlas for the Mouse Brain

Despite vast numbers of studies of stained cells in the mouse brain, no current brain atlas provides region-by-region neuron counts. In fact, neuron numbers are only available for about 4% of brain of regions and estimates often vary by as much as 3-fold. Here we provide a first 3D cell atlas for th...

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Bibliographic Details
Published inFrontiers in neuroinformatics Vol. 12; p. 84
Main Authors Erö, Csaba, Gewaltig, Marc-Oliver, Keller, Daniel, Markram, Henry
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 28.11.2018
Frontiers Media S.A
Subjects
Allen brain atlas
Astrocytes
Brain
Cell adhesion & migration
cell numbers
Estimates
Gene expression
glia
Microglia
Microscopy
mouse brain
Neurons
Neuroscience
Neurosciences
Oligodendrocytes
Science
mouse brain
cell numbers
glia
neurons
Allen brain atlas
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Summary:Despite vast numbers of studies of stained cells in the mouse brain, no current brain atlas provides region-by-region neuron counts. In fact, neuron numbers are only available for about 4% of brain of regions and estimates often vary by as much as 3-fold. Here we provide a first 3D cell atlas for the whole mouse brain, showing cell positions constructed algorithmically from whole brain Nissl and gene expression stains, and compared against values from the literature. The atlas provides the densities and positions of all excitatory and inhibitory neurons, astrocytes, oligodendrocytes, and microglia in each of the 737 brain regions defined in the AMBA. The atlas is dynamic, allowing comparison with previously reported numbers, addition of cell types, and improvement of estimates as new data is integrated. The atlas also provides insights into cellular organization only possible at this whole brain scale, and is publicly available.
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Edited by: Qingming Luo, Huazhong University of Science and Technology, China
Second senior author
Reviewed by: Jingpeng Wu, Princeton University, United States; Hong-Wei Dong, Laboratory of Neuro Imaging-University of Southern California, United States
ISSN:1662-5196
1662-5196
DOI:10.3389/fninf.2018.00084