Resting State fMRI: Going Through the Motions

• Published in: Frontiers in neuroscience Vol. 13; p. 825
• Main Authors: Maknojia, Sanam, Churchill, Nathan W., Schweizer, Tom A., Graham, S. J.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 13.08.2019; Frontiers Media S.A
• Subjects: Algorithms; Brain research; Functional magnetic resonance imaging; image processing; Medical research; motion artifacts; motion compensation; Nervous system; Neural networks; Neuroscience; NMR; noise; Nuclear magnetic resonance; Quality control; resting state fMRI; Canada; image processing; noise; motion artifacts; resting state fMRI; motion compensation
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2019.00825

Resting state functional magnetic resonance imaging (rs-fMRI) has become an indispensable tool in neuroscience research. Despite this, rs-fMRI signals are easily contaminated by artifacts arising from movement of the head during data collection. The artifacts can be problematic even for motions on the millimeter scale, with complex spatiotemporal properties that can lead to substantial errors in functional connectivity estimates. Effective correction methods must be employed, therefore, to distinguish true functional networks from motion-related noise. Research over the last three decades has produced numerous correction methods, many of which must be applied in combination to achieve satisfactory data quality. Subject instruction, training, and mild restraints are helpful at the outset, but usually insufficient. Improvements come from applying multiple motion correction algorithms retrospectively after rs-fMRI data are collected, although residual artifacts can still remain in cases of elevated motion, which are especially prevalent in patient populations. Although not commonly adopted at present, "real-time" correction methods are emerging that can be combined with retrospective methods and that promise better correction and increased rs-fMRI signal sensitivity. While the search for the ideal motion correction protocol continues, rs-fMRI research will benefit from good disclosure practices, such as: (1) reporting motion-related quality control metrics to provide better comparison between studies; and (2) including motion covariates in group-level analyses to limit the extent of motion-related confounds when studying group differences.