Powerful Statistical Inference for Nested Data Using Sufficient Summary Statistics

• Published in: Frontiers in human neuroscience Vol. 12; p. 103
• Main Authors: Dowding, Irene, Haufe, Stefan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 19.03.2018; Frontiers Media S.A
• Subjects: Economic models; EEG; group-level effect size; hierarchical inference; Hypotheses; inverse-variance-weighting; Medical imaging; Nervous system; Neuroscience; Parameter estimation; Power; significance test; Statistical analysis; Statistical inference; Statistical power; Statistics; Studies; sufficient summary statistic; sufficient summary statistic; significance test; statistical power; Stouffer's method; hierarchical inference; group-level effect size; event-related potentials; inverse-variance-weighting
• ISSN: 1662-5161; 1662-5161
• DOI: 10.3389/fnhum.2018.00103

Hierarchically-organized data arise naturally in many psychology and neuroscience studies. As the standard assumption of independent and identically distributed samples does not hold for such data, two important problems are to accurately estimate group-level effect sizes, and to obtain powerful statistical tests against group-level null hypotheses. A common approach is to summarize subject-level data by a single quantity per subject, which is often the mean or the difference between class means, and treat these as samples in a group-level -test. This "naive" approach is, however, suboptimal in terms of statistical power, as it ignores information about the intra-subject variance. To address this issue, we review several approaches to deal with nested data, with a focus on methods that are easy to implement. With what we call the sufficient-summary-statistic approach, we highlight a computationally efficient technique that can improve statistical power by taking into account within-subject variances, and we provide step-by-step instructions on how to apply this approach to a number of frequently-used measures of effect size. The properties of the reviewed approaches and the potential benefits over a group-level -test are quantitatively assessed on simulated data and demonstrated on EEG data from a simulated-driving experiment.