Functional Compensation by Transplantation of Cell Suspensions of Embryonic Mesencephalon into the Striatum of Rats with 6-Hydroxydopamine Lesions

Neuronal cell suspensions were implanted into the striatum of female rats that showed apomorphine-induced rotation and a reduction in striatal dopamine after intranigral treatment with 6-hydroxydopamine. The apomorphine-induced rotation was significantly suppressed by the transplantation in 12 out o...

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Published inJapanese journal of pharmacology Vol. 40; no. 4; pp. 591 - 593
Main Authors WATANABE, Hiroshi, HIYAMA, Yukitaka, SUDA, Hiroshi, SEKIHARA, Shun-ichi, TERASAWA, Katsutoshi
Format Journal Article
LanguageEnglish
Published Japan The Japanese Pharmacological Society 1986
Subjects
Animals
Apomorphine - pharmacology
Corpus Striatum - physiology
Dihydroxyphenylalanine - metabolism
Dopamine - metabolism
Female
Hydrazines - pharmacology
Hydroxydopamines - pharmacology
Mesencephalon - cytology
Mesencephalon - transplantation
Oxidopamine
Rats
Rats, Inbred Strains
Spiperone - pharmacology
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Summary:Neuronal cell suspensions were implanted into the striatum of female rats that showed apomorphine-induced rotation and a reduction in striatal dopamine after intranigral treatment with 6-hydroxydopamine. The apomorphine-induced rotation was significantly suppressed by the transplantation in 12 out of 64 rats. DOPA accumulation and dopamine level (6.3 and 3.4%, respectively, compared with those of uncompensated rats) in the striatum following treatment with an amino acid decarboxylase inhibitor were slightly restored in compensated rats.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.40.591