Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor of the Spleen with Extensive Histiocytic Granulomas and Necrosis: A Case Report and Literature Review

• Published in: Journal of pathology and translational medicine Vol. 47; no. 6; pp. 599 - 602
• Main Authors: Kim, Hyun-Jung, Kim, Ji Eun, Kang, Gu-Hyun, Kim, Jung Yeon, Park, Kyeongmee
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society of Pathologists, Korean Society for Cytopathology 01.12.2013; The Korean Society of Pathologists and The Korean Society for Cytopathology; 대한병리학회
• Subjects: Brief Case Report; Immune system; Lymphocytes; Pathogenesis; Spleen; Tomography; 병리학
• ISSN: 1738-1843; 2383-7837; 2092-8920; 2383-7845
• DOI: 10.4132/KoreanJPathol.2013.47.6.599

Inflammatory pseudotumor (IPT)-like follicular dendritic cell tumor (FDCT) has been recently designated1 and character- ized by proliferation of Epstein-Barr vims (EBV)-positive fol- licular dendritic cell (FDC) and commonly occurs in the liver and spleen.2'9 Histologically, it is characterized by spindle cell proliferation admixed with abundant inflammatory cells, main- ly lymphocytes and plasma cells. At present, the preferred term 'inflammatory myofibroblastic tumor' is used, because it has been shown that the proliferating spindle cells show a myofi- broblastic phenotype in many cases.1 About 20 cases have been reported,2,9 although only one case has been reported in Korea.9 We present here a rare case of IPT-like FDCT of the spleen with extensive histiocytic granulomas and necrosis, including a brief literature review.