Uric Acid Has Different Effects on Spontaneous Brain Activities of Males and Females: A Cross-Sectional Resting-State Functional MR Imaging Study

• Published in: Frontiers in neuroscience Vol. 13; p. 763
• Main Authors: Lin, Li, Zheng, Li Juan, Joseph Schoepf, U, Varga-Szemes, Akos, Savage, Rock H, Wang, Yun Fei, Zhang, Han, Zhang, Xin Yuan, Lu, Guang Ming, Zhang, Long Jiang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 26.07.2019; Frontiers Media S.A
• Subjects: amplitude of low-frequency fluctuation; blood oxygen level dependent; Brain mapping; Cholesterol; Chronic illnesses; Cognitive ability; cognitive function; Consciousness; Correlation analysis; Dementia; Disease; Executive function; Females; Functional magnetic resonance imaging; Globus pallidus; Hyperuricemia; Males; Medical imaging; Medical research; Mutation; Neuroimaging; Neuroscience; Older people; Putamen; Researchers; resting-stage functional magnetic resonance imaging; Rheumatism; Stroke; Studies; Traumatic brain injury; Uric acid; Young adults; United States > US; cognitive function; amplitude of low-frequency fluctuation; resting-stage functional magnetic resonance imaging; blood oxygen level dependent; uric acid
• ISSN: 1662-4548; 1662-453X; 1662-453X
• DOI: 10.3389/fnins.2019.00763

To explore the relationship among serum uric acid (SUA) levels in different states of disease, human cognition, and spontaneous brain activities by resting-state functional MRI (rs-fMRI). We prospectively recruited 100 subjects (age 58 ± 11 years, 55 females) who underwent fasting blood sampling, cognitive tests and rs-fMRI scans. The subjects were divided into two groups by sex and each sex group was further stratified into three subgroups according to SUA level in different states of disease. The amplitude of low-frequency fluctuation (ALFF) method was applied to assess spontaneous brain activity among groups. Pearson's correlation analysis was used to investigate the relationships between the mean ALFF values (mALFF) and cognitive tests. A total of 97 patients completed the study protocol successfully. Significant differences in age, education level, number connection test (NCT), and word fluency were observed among the three subgroups in males (all < 0.05). Results of group-by-sex interaction were distributed in bilateral pallidum and putamen [voxel -value < 0.001, cluster -value < 0.05, Gaussian random field (GRF)-corrected]. The tendency of the SUA effect on mALFF was different in males and females, particularly in corresponding High SUA subgroups (that is pre-hyperuricemia, both < 0.001). Among the male subjects, mALFF values of the bilateral pallidum and putamen negatively correlated with attention/executive function. Our results suggest that elevated SUA levels have different effects on spontaneous brain activities and cognitive function in males and females. Males with pre-hyperuricemia and hyperuricemia are more susceptible to changes in spontaneous brain activities and lower neuropsychological assessment scores, particularly in word fluency tests and NCT, compared to females.