Cytomegalovirus retinitis as an adverse immunological effect of pulses of vincristine and dexamethasone in maintenance therapy for childhood acute lymphoblastic leukemia

We describe a 5‐year‐old female with acute lymphoblastic leukemia (ALL) who suffered from cytomegalovirus (CMV) retinitis during maintenance therapy consisting of 6‐mercaptopurine (6‐MP) and methotrexate (MTX) with pulses of vincristine (VCR) and dexamethasone (DEX). Administration of anticytomegalo...

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Published inPediatric blood & cancer Vol. 60; no. 2; pp. 329 - 331
Main Authors Moritake, Hiroshi, Kamimura, Sachiyo, Kojima, Hitomi, Shimonodan, Hidemi, Harada, Masako, Sugimoto, Takako, Nao-i, Nobuhisa, Nunoi, Hiroyuki
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2013
Wiley Subscription Services, Inc
Subjects
acute lymphoblastic leukemia
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Child, Preschool
cytomegalovirus retinitis
Cytomegalovirus Retinitis - chemically induced
dexamethasone
Dexamethasone - administration & dosage
Dexamethasone - adverse effects
Female
Hematology
Herpesviridae
Humans
Maintenance Chemotherapy - adverse effects
Maintenance Chemotherapy - methods
maintenance therapy
Mercaptopurine - administration & dosage
Mercaptopurine - adverse effects
Methotrexate - administration & dosage
Methotrexate - adverse effects
Oncology
Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
vincristine
Vincristine - administration & dosage
Vincristine - adverse effects
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Summary:We describe a 5‐year‐old female with acute lymphoblastic leukemia (ALL) who suffered from cytomegalovirus (CMV) retinitis during maintenance therapy consisting of 6‐mercaptopurine (6‐MP) and methotrexate (MTX) with pulses of vincristine (VCR) and dexamethasone (DEX). Administration of anticytomegaloviral drugs led to a complete regression of active retinitis. Her low CD4 positive T cells and serum immunoglobulin G (IgG) recovered when maintenance therapy was resumed without VCR and DEX. The patient has been in complete remission (CR) for more than 5 months after completion of maintenance therapy without recurrence of CMV retinitis. Pediatr Blood Cancer 2013;60:329–331. © 2012 Wiley Periodicals, Inc.
Bibliography:istex:0B13DC1E3C68510A7954E5C578D91F4698863F15
ark:/67375/WNG-GT1KSPTZ-D
Conflict of interest: Nothing to declare.
ArticleID:PBC24298
ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ObjectType-Article-1
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ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.24298