Risk factors influencing antibody responses to Kaposi's sarcoma-associated herpesvirus latent and lytic antigens in patients under antiretroviral therapy

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 56; no. 1; p. 83
• Main Authors: Guadalupe, Moraima, Pollock, Brad H, Westbrook, Steven, Redding, Spencer, Bullock, Delia, Anstead, Gregory, Agan, Brian K, Marconi, Vincent C, Barbieri, Sharon, Sankar, Vidya, Rebeles, Jennifer, Flahive, Yvette, Schoolfield, John, Wang, Linding, Lei, Xiufen, Dow, Dorothy, Yeh, Chih-Ko, Dang, Howard, Infante, Anthony J, Gao, Shou-Jiang
• Format: Journal Article
• Language: English
• Published: United States 01.01.2011
• Subjects: Adult; AIDS-Related Opportunistic Infections - immunology; Anti-HIV Agents - therapeutic use; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody Formation - immunology; Antigens, Viral - blood; Antigens, Viral - immunology; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-CD8 Ratio; Female; Herpesvirus 8, Human - immunology; Herpesvirus 8, Human - physiology; Humans; Male; Middle Aged; Multivariate Analysis; Risk Factors; Sarcoma, Kaposi - immunology; Sarcoma, Kaposi - virology; Viral Load - immunology; Virus Latency - immunology
• ISSN: 1944-7884
• DOI: 10.1097/QAI.0b013e3181fdc928

Kaposi's sarcoma-associated herpesvirus (KSHV) seropositivity and lytic antibody titer are predictors for Kaposi's sarcoma. We examined demographic, viral, and immunologic factors that influence KSHV latent and lytic antibodies in HIV-infected patients. Detection rate of KSHV latent but not lytic antibodies was lower in patients with CD4 cells/mm3 less than 200 than greater than 200 (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.11-0.61) and CD8 cells/mm3 less than 400 than greater than 400 (OR, 0.26; 95% CI, 0.07-0.67). Overall seropositivity rate was higher in patients with CD4 cells/mm3 less than 200 than greater than 200 (OR, 2.34; 95% CI, 1.37-4.02) and HIV copies/mL greater than 400 than less than 400 (OR, 1.70; 95% CI, 1.09-2.65). Lytic antibody level was inversely correlated with CD4 count (P < 0.001). Lytic seropositivity (OR, 2.47; 95% CI, 1.35-4.50) and antibody level (adjusted difference mean optical density, 0.324; 95% CI, 0.16-0.46) were higher in patients with HIV infection greater than 15 than less than 15 years. Hispanics had higher lytic seropositivity rate (OR, 1.71; 95% CI, 1.07-2.73) and antibody level (adjusted difference mean optical density, 0.111; 95% CI, 0.03-0.18) than non-Hispanics. Lower CD4 and CD8 counts impair antibody response to KSHV latent antigens. Immune deterioration, long-term HIV infection, and Hispanic status are risk factors for Kaposi's sarcoma predictors.