Is PPARα intron 7 G/C polymorphism associated with muscle strength characteristics in nonathletic young men?
Peroxisome proliferator‐activated receptor alpha (PPARα), a ligand‐dependent transcription factor, regulates fatty acid metabolism in heart and skeletal muscle. The intron 7 G/C polymorphism (rs4253778) has been associated with athletic performance. The rare C‐allele was predominant in power athlete...
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Published in | Scandinavian journal of medicine & science in sports Vol. 23; no. 4; pp. 494 - 500 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Denmark
Blackwell Publishing Ltd
01.08.2013
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Subjects | |
Online Access | Get full text |
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Summary: | Peroxisome proliferator‐activated receptor alpha (PPARα), a ligand‐dependent transcription factor, regulates fatty acid metabolism in heart and skeletal muscle. The intron 7 G/C polymorphism (rs4253778) has been associated with athletic performance. The rare C‐allele was predominant in power athletes, whereas the G‐allele was more frequent in endurance athletes. In the present study, we investigated the association between this polymorphism and strength characteristics in nonathletic, healthy young adults (n = 500; age 24.2 ± 4.4 years). Knee torque was measured during concentric knee flexion and extension movements at 60°/s, 120°/s, and 240°/s during 3, 25, and 5 repetitions, respectively. Also, resistance to muscle fatigue (i.e. work last 20% repetitions/work first 20% repetitions *100) was calculated. Differences in knee strength phenotypes between GG homozygous individuals and C‐allele carriers were analyzed. The polymorphism did not influence the ability to produce isometric or dynamic knee flexor or extensor peak torque during static or dynamic conditions in this population (0.23 < P < 0.95). Similar results were found for the endurance ratio, a measure for resistance to muscle fatigue. In conclusion, the PPARα intron 7 G/C polymorphism does not seem to influence strength characteristics in a nonathletic population. |
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Bibliography: | Research Foundation of the Katholieke Universiteit Leuven (OT) - No. OT/04/44 Fund for Scientific Research - Flanders (FWO) - No. G.0496.05; No. G.0567.07 istex:3ABC0C19F41AC8334DC60F4109E93AC22DD4F3A7 ark:/67375/WNG-FKBMFTMT-H ArticleID:SMS1406 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0905-7188 1600-0838 |
DOI: | 10.1111/j.1600-0838.2011.01406.x |