Accomplishments in genome-scale in silico modeling for industrial and medical biotechnology

Driven by advancements in high-throughput biological technologies and the growing number of sequenced genomes, the construction of in silico models at the genome scale has provided powerful tools to investigate a vast array of biological systems and applications. Here, we review comprehensively the...

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Bibliographic Details
Published inBiotechnology journal Vol. 4; no. 12; p. 1653
Main Authors Milne, Caroline B, Kim, Pan-Jun, Eddy, James A, Price, Nathan D
Format Journal Article
LanguageEnglish
Published Germany 01.12.2009
Subjects
Bacteria - genetics
Bacterial Physiological Phenomena
Biomedical Technology
Biotechnology
Computer Simulation
Genomics - methods
Industrial Microbiology
Models, Biological
Systems Biology
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Summary:Driven by advancements in high-throughput biological technologies and the growing number of sequenced genomes, the construction of in silico models at the genome scale has provided powerful tools to investigate a vast array of biological systems and applications. Here, we review comprehensively the uses of such models in industrial and medical biotechnology, including biofuel generation, food production, and drug development. While the use of in silico models is still in its early stages for delivering to industry, significant initial successes have been achieved. For the cases presented here, genome-scale models predict engineering strategies to enhance properties of interest in an organism or to inhibit harmful mechanisms of pathogens. Going forward, genome-scale in silico models promise to extend their application and analysis scope to become a trans-formative tool in biotechnology.
ISSN:1860-7314
DOI:10.1002/biot.200900234