IgE Sensitization to the Fish Parasite Anisakis simplex in a Norwegian Population: A Pilot Study

• Published in: Scandinavian journal of immunology Vol. 75; no. 4; pp. 431 - 435
• Main Authors: Lin, A. H., Florvaag, E., Van Do, T., Johansson, S. G. O., Levsen, A., Vaali, K.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2012
• Subjects: Animals; Anisakis - immunology; Anisakis simplex; Antibodies, Helminth - immunology; Cross Reactions; Dermatophagoides pteronyssinus; Fish Products - adverse effects; Fish Products - parasitology; Fishes - parasitology; Food Hypersensitivity - epidemiology; Food Hypersensitivity - immunology; Food Hypersensitivity - parasitology; Immunoglobulin E - immunology; Marine; Medicin och hälsovetenskap; Norway - epidemiology; Pilot Projects; Prevalence; Norway; Norway, Hordaland, Bergen
• ISSN: 0300-9475; 1365-3083; 1365-3083
• DOI: 10.1111/j.1365-3083.2012.02670.x

The reports on fish parasite Anisakis simplex allergy have increased in countries with high fish consumption in the last decade. In Norway, a high consumption country, the prevalence of immunoglobulin E (IgE) sensitization to A. simplex was still unknown. Thus, our objective was to investigate the sensitization prevalence in this country. At the Haukeland University Hospital, Bergen, Norway, two main groups of surplus serum samples were collected: one from newly recruited blood donors (BDO) and the other from the Allergy laboratory (ALL) after analysing IgE and IgE antibodies. The latter was divided into three series: one containing unsorted sera and two sorted by either Phadiatop®≥0.35 kUA/l or total IgE ≥1000 kU/l. The sera were analysed for total IgE and IgE antibodies against A. simplex, shrimp, house dust mite (HDM), cod and cross‐reactive carbohydrates (CCDs). The prevalence of IgE sensitization to A. simplex was 2.0%, 2.2% and 6.6% in BDO, the unsorted and Phadiatop® positive serum groups, respectively. A considerable degree of cross‐sensitization to shrimp and HDM is further suggested. Unspecific binding because of high total IgE or by binding to CCDs seemed to play a minor role. The prevalence of IgE sensitization to A. simplex appears to be lower in a Norwegian population than in other high fish‐consuming countries, but might still be overestimated owing to cross‐sensitization.