The metabolic programming of stem cells

Advances in metabolomics have deepened our understanding of the roles that specific modes of metabolism play in programming stem cell fates. Here, we review recent metabolomic studies of stem cell metabolism that have revealed how metabolic pathways can convey changes in the extrinsic environment or...

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Bibliographic Details
Published inGenes & development Vol. 31; no. 4; pp. 336 - 346
Main Authors Shyh-Chang, Ng, Ng, Huck-Hui
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 15.02.2017
Subjects
Animals
Cell Differentiation
Environment
Humans
Metabolic Networks and Pathways
Metabolome
Review
Stem Cells - cytology
Stem Cells - metabolism
stem cell
metabolomics
oxidative phosphorylation
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ISSN0890-9369
1549-5477
1549-5477
DOI10.1101/gad.293167.116

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Summary:Advances in metabolomics have deepened our understanding of the roles that specific modes of metabolism play in programming stem cell fates. Here, we review recent metabolomic studies of stem cell metabolism that have revealed how metabolic pathways can convey changes in the extrinsic environment or their niche to program stem cell fates. The metabolic programming of stem cells represents a fine balance between the intrinsic needs of a cellular state and the constraints imposed by extrinsic conditions. A more complete understanding of these needs and constraints will afford us greater mastery over our control of stem cell fates.
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ISSN:0890-9369
1549-5477
1549-5477
DOI:10.1101/gad.293167.116