Oat bran increases serum acetate of hypercholesterolemic men

• Published in: The American journal of clinical nutrition Vol. 56; no. 2; pp. 455 - 459
• Main Authors: Bridges, SR, Anderson, JW, Deakins, DA, Dillon, DW, Wood, CL
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.08.1992; American Society for Clinical Nutrition
• Subjects: ACETATE; Acetates - blood; ACETATOS; ACIDE GRAS; ACIDOS GRASOS; Adult; Aged; AVENAS; AVOINE; Biological and medical sciences; BLE; CHOLESTEROL; COLESTEROL; COMPLEMENTATION; DIETA; Dietary Fiber - therapeutic use; Disorders of blood lipids. Hyperlipoproteinemia; Edible Grain; ENRIQUECIMIENTO DE LOS ALIMENTOS; EXPERIMENTATION; EXPERIMENTOS; Fatty Acids, Volatile - blood; HOMBRES; HOMME; Humans; Hypercholesterolemia - blood; Hypercholesterolemia - diet therapy; LIPEMIA; LIPEMIE; Lipids - blood; Male; Medical sciences; MEDICAMENT; MEDICAMENTOS; Metabolic diseases; Middle Aged; Oat bran; REGIME ALIMENTAIRE; SALVADO; serum acetate; serum cholesterol; SERUM SANGUIN; SON; SUERO SANGUINEO; TRASTORNOS METABOLICOS; TRIGO; TROUBLE DU METABOLISME; serum acetate; serum cholesterol; Oat bran; Human; Oat; Metabolic diseases; Lipids; Supplemented diet; Acetate; Cholesterol; Hypercholesterolemia; Diet therapy; Diet; Serum; Dietary fiber; Mechanism of action
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/56.2.455

Mechanisms for the hypocholesterolemic effects of oat bran remain unclear. Soluble fibers such as oat bran are fermented in the colon to short-chain fatty acids (SCFAs), which may enter the portal vein and attenuate hepatic cholesterol synthesis. To compare effects of oat bran and wheat bran on serum SCFA concentrations, 20 hypercholesterolemic men entered a metabolic ward and received control diets for 1 wk followed by oat-bran or wheat-bran diets for 3 wk. Oat bran decreased serum cholesterol 12.8% (P < 0.001) whereas wheat bran had no effect. Peripheral serum SCFA concentrations were measured seven times over 14 h at the end of each diet. Serum acetate values from 1200 to 2200 were significantly higher in subjects fed oat-bran vs wheat-bran diets. Peak and incremental peak acetate values were also significantly higher than control values in subjects fed oat bran but not in subjects fed wheat bran. SCFA responses may contribute to the hypocholesterolemic effects of oat bran.