Genetic variability of CYP2B6 polymorphisms in four southern Chinese populations

• Published in: World journal of gastroenterology : WJG Vol. 13; no. 14; pp. 2100 - 2103
• Main Author: Xu, Bing-Ying
• Format: Journal Article
• Language: English
• Published: United States Kunming Medical College, Kunming 650032, Yunnan Province, China%Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China%Stanley Ho Center for Emerging Infectious Diseases, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China%Kunming Medical College, Kunming 650032, Yunnan Province, China 14.04.2007; Stanley Ho Center for Emerging Infectious Diseases, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China%Hong Kong Red Cross Blood Transfusion Service, Hong Kong, China; Baishideng Publishing Group Inc
• Subjects: Adult; Anti-HIV Agents - metabolism; Anti-HIV Agents - therapeutic use; Aryl Hydrocarbon Hydroxylases - genetics; Asian Continental Ancestry Group - genetics; Benzoxazines - metabolism; Benzoxazines - therapeutic use; China; Cytochrome P-450 CYP2B6; Female; Gene Frequency; Genetic Variation; Genotype; Heroin Dependence - drug therapy; Heroin Dependence - ethnology; HIV Infections - drug therapy; HIV Infections - ethnology; Humans; Male; Oxidoreductases, N-Demethylating - genetics; Polymorphism, Genetic - genetics; Rapid Communication; China; Genotype; Allele; Ethnicity; Discrimination PCR; Polymorphism
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v13.i14.2100

To investigate the genotype and allelic frequencies of Cytochrome P450 2B6 polymorphisms in four southern Chinese populations. DNA was obtained from blood samples from Han Chinese from Hong Kong and three minority groups, the Wa, Bulang and Lahu from Yunnan in southern China. Genotyping was performed using real-time PCR and confirmed by direct sequencing. A total of 507 subjects from southern China were studied. Results showed there is a high prevalence of 516G > T (34.5%) in ethnic Chinese compared to literature reports on other Asian populations and Caucasians. The frequency of the 516TT genotype is higher in the Han majority (23.1%) than in three other ethnic minority groups (i.e., 7.4%, 9.1% and 15.8%) in southern China. This was the first study to document the spectrum of CYP2B6 allelic variants and genotypes in a southern Chinese population. The 516G > T allele is associated with a defective metabolism of efavirenz (EFV), which therefore may predispose to drug toxicity. Treatment regimens for human immunodeficiency virus (HIV) and heroin addiction may need to be optimized in different populations because of the marked variability of the key metabolizing enzyme.