Mechanisms of metabolic dysfunction in cancer-associated cachexia

Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the adipose tissue. This systemic syndrome, termed cancer-associated cachexia (CAC), is a major cause of morbidity and mor...

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Bibliographic Details
Published inGenes & development Vol. 30; no. 5; pp. 489 - 501
Main Authors Petruzzelli, Michele, Wagner, Erwin F
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.03.2016
Subjects
Adipose Tissue, White - physiopathology
Cachexia - etiology
Cachexia - physiopathology
Carbohydrate Metabolism - physiology
Endocrine System - physiopathology
Humans
Inflammation - complications
Lipid Metabolism
Liver - physiopathology
Muscular Atrophy - etiology
Neoplasms - complications
Review
cancer-associated cachexia (CAC)
white adipose tissue (WAT) browning
skeletal muscle atrophy
metabolic failure
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Summary:Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the adipose tissue. This systemic syndrome, termed cancer-associated cachexia (CAC), is a major cause of morbidity and mortality. While once attributed solely to decreased food intake, the present description of cancer cachexia is a disorder of multiorgan energy imbalance. Here we review the molecules and pathways responsible for metabolic dysfunction in CAC and the ideas that led to the current understanding.
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ISSN:0890-9369
1549-5477
DOI:10.1101/gad.276733.115