Synthesis and anti-microbial activity of hydroxylammonium ionic liquids

• Published in: Chemosphere (Oxford) Vol. 84; no. 1; pp. 101 - 104
• Main Authors: Ismail Hossain, M., El-Harbawi, Mohanad, Noaman, Yousr Abdulhadi, Bustam, Mohd Azmi B., Alitheen, Noorjahan Banu Mohamed, Affandi, Nor Azrin, Hefter, Glenn, Yin, Chun-Yang
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.06.2011; Elsevier
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - toxicity; Anti-microbial screening; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Disinfectants - chemical synthesis; Disinfectants - toxicity; Human pathogens; Hydroxyl ammonium ionic liquids; Hydroxylamine - chemical synthesis; Hydroxylamine - toxicity; Inhibition potential; Ionic Liquids - chemical synthesis; Ionic Liquids - toxicity; Magnetic Resonance Spectroscopy; Medical sciences; Pharmacology. Drug treatments; Spectrophotometry, Infrared; Staphylococcus aureus; Staphylococcus aureus - drug effects; Hydroxyl ammonium ionic liquids; Human pathogens; Anti-microbial screening; Inhibition potential; Human; Ammonium; Antimicrobial agent; Liquid; Pathogenic; Inhibition; Microorganism; Chemical synthesis; Hydroxyl
• ISSN: 0045-6535; 1879-1298
• DOI: 10.1016/j.chemosphere.2011.02.048

[Display omitted] ► We synthesize eight new room temperature ionic liquids (ILs). ► Synthesis is via acid–base neutralization of ethanolamines with organic acids. ► Characterization is via IR and NMR spectroscopies and elemental analysis. ► All eight ILs are toxic to Staphylococcus aureus. ► Two ILs show high anti-microbial activity against a wide range of human pathogens. Eight hydroxylammonium-based room temperature ionic liquids (ILs) have been synthesized by acid–base neutralization of ethanolamines with organic acids. The ILs were characterized by infrared and nuclear magnetic resonance spectroscopies and elemental analysis. Their anti-microbial activities were determined using the well-diffusion method. All eight ILs were toxic to Staphylococcus aureus, while 2-hydroxyethylammonium lactate and 2-hydroxy-N-(2-hydroxyethyl)-N-methylethanaminium acetate showed high anti-microbial activity against a wide range of human pathogens.