Establishment of an ideal time window model in hypothermic-targeted temperature management after traumatic brain injury in rats

• Published in: Brain research Vol. 1669; pp. 141 - 149
• Main Authors: Zhao, Wan-Yong, Chen, Shao-Bo, Wang, Jing-Jing, Xu, Chao, Zhao, Ming-Liang, Dong, Hua-Jiang, Liang, Hai-Qian, Li, Xiao-Hong, Tu, Yue, Zhang, Sai, Chen, Chong, Sun, Hong-Tao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2017
• Subjects: Animals; Apoptosis; Astrocytes - pathology; Astrocytes - physiology; bcl-2-Associated X Protein - metabolism; Brain Edema - pathology; Brain Edema - physiopathology; Brain Edema - therapy; Brain Injuries, Traumatic - pathology; Brain Injuries, Traumatic - physiopathology; Brain Injuries, Traumatic - therapy; Caspase 3 - metabolism; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Disease Models, Animal; Effect; Glial Fibrillary Acidic Protein - metabolism; Gliosis - pathology; Gliosis - physiopathology; Gliosis - therapy; Hippocampus - metabolism; Hippocampus - pathology; Hypothermia, Induced - methods; Hypothermic-targeted temperature management; Male; Microtubule-Associated Proteins - metabolism; Neurogenesis - physiology; Neurology; Neurons - pathology; Neurons - physiology; Neuropeptides - metabolism; Neuroprotection; Proto-Oncogene Proteins c-bcl-2 - metabolism; Random Allocation; Rats, Sprague-Dawley; Time Factors; Time window; Traumatic brain injury; Traumatic brain injury; Hypothermic-targeted temperature management; Time window; HTTM; MHT; TBI; Effect; Mild hypothermia
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2017.06.006

Highlights • Hypothermic-targeted temperature management improved histopathology and behavioral outcomes of TBI rats. • Delayed hypothermic-targeted temperature management displayed beneficial neuroprotective effects likewise in rats experiments. • Appropriate postponed implementation of hypothermic-targeted temperature management was more in accordance with clinical treatment process. • An ideal time window model of hypothermic-targeted temperature management could be applied to the following fundamental researches.