Repeated propofol anesthesia induced downregulation of hippocampal miR-132 and learning and memory impairment of rats

• Published in: Brain research Vol. 1670; pp. 156 - 164
• Main Authors: Zhang, Shuo, Liang, Zuodi, Sun, Wenchong, Pei, Ling
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2017
• Subjects: Anesthesia; Anesthetics, Intravenous - pharmacology; Anesthetics, Intravenous - toxicity; Animals; Animals, Newborn; Dendritic Spines - drug effects; Dendritic Spines - metabolism; Down-Regulation - drug effects; Female; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Male; Maze Learning - drug effects; Memory - drug effects; Memory Disorders - chemically induced; Memory Disorders - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; miR-132; Neurology; Neurotoxicity; Pregnancy; Propofol; Propofol - pharmacology; Propofol - toxicity; Rats; Rats, Sprague-Dawley; neurotoxicity; Propofol; hippocampus; miR-132; anesthesia; Anesthesia; Neurotoxicity; Hippocampus
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2017.04.011

Highlights • Propofol causes sequential changes of miR-132 and its related protein of hippocampus. • Neonatal exposure to propofol causes neurodevelopmental damage. • Propofol causes decrease in the number of dendritic spines in the hippocampus.