Antioxidant and antiasthmatic effects of saucerneol D in a mouse model of airway inflammation
Chronic airway inflammation is a hallmark of asthma, which is an immune-based disease. We evaluated the ability of saucerneol D, a tetrahydrofuran-type sesquilignan isolated from Saururus chinensis, to regulate airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Furthermore,...
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Published in | International immunopharmacology Vol. 11; no. 6; pp. 698 - 705 |
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Main Authors | , , , , , |
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Language | English |
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01.06.2011
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Abstract | Chronic airway inflammation is a hallmark of asthma, which is an immune-based disease. We evaluated the ability of saucerneol D, a tetrahydrofuran-type sesquilignan isolated from
Saururus chinensis, to regulate airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Furthermore, we determined whether heme oxygenase (HO)-1 was required for the protective activity of saucerneol D. The airways of OVA-sensitized mice exposed to an OVA challenge developed eosinophilia and mucus hypersecretion and exhibited increased cytokine levels. Mice were administered saucerneol D orally at doses of 20 and 40
mg/kg once daily on days 26–30. Saucerneol D administered orally significantly inhibited the number of OVA-induced inflammatory cells and the production of immunoglobulin E as well as Th2-type cytokines. Histopathology studies revealed a marked decrease in lung inflammation and goblet cell hyperplasia after saucerneol D treatment. In addition, saucerneol D induced HO-1 and led to a marked decrease in OVA-induced reactive oxygen species and malondialdehyde and an increase in superoxide dismutase and glutathione in lung tissues. These antioxidant effects were correlated with HO-1 induction. In our experiments, saucerneol D treatment reduced airway inflammation and suppressed oxidative stress in an OVA-induced asthma model. |
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AbstractList | Chronic airway inflammation is a hallmark of asthma, which is an immune-based disease. We evaluated the ability of saucerneol D, a tetrahydrofuran-type sesquilignan isolated from Saururus chinensis, to regulate airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Furthermore, we determined whether heme oxygenase (HO)-1 was required for the protective activity of saucerneol D. The airways of OVA-sensitized mice exposed to an OVA challenge developed eosinophilia and mucus hypersecretion and exhibited increased cytokine levels. Mice were administered saucerneol D orally at doses of 20 and 40mg/kg once daily on days 26-30. Saucerneol D administered orally significantly inhibited the number of OVA-induced inflammatory cells and the production of immunoglobulin E as well as Th2-type cytokines. Histopathology studies revealed a marked decrease in lung inflammation and goblet cell hyperplasia after saucerneol D treatment. In addition, saucerneol D induced HO-1 and led to a marked decrease in OVA-induced reactive oxygen species and malondialdehyde and an increase in superoxide dismutase and glutathione in lung tissues. These antioxidant effects were correlated with HO-1 induction. In our experiments, saucerneol D treatment reduced airway inflammation and suppressed oxidative stress in an OVA-induced asthma model. Chronic airway inflammation is a hallmark of asthma, which is an immune-based disease. We evaluated the ability of saucerneol D, a tetrahydrofuran-type sesquilignan isolated from Saururus chinensis, to regulate airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Furthermore, we determined whether heme oxygenase (HO)-1 was required for the protective activity of saucerneol D. The airways of OVA-sensitized mice exposed to an OVA challenge developed eosinophilia and mucus hypersecretion and exhibited increased cytokine levels. Mice were administered saucerneol D orally at doses of 20 and 40 mg/kg once daily on days 26–30. Saucerneol D administered orally significantly inhibited the number of OVA-induced inflammatory cells and the production of immunoglobulin E as well as Th2-type cytokines. Histopathology studies revealed a marked decrease in lung inflammation and goblet cell hyperplasia after saucerneol D treatment. In addition, saucerneol D induced HO-1 and led to a marked decrease in OVA-induced reactive oxygen species and malondialdehyde and an increase in superoxide dismutase and glutathione in lung tissues. These antioxidant effects were correlated with HO-1 induction. In our experiments, saucerneol D treatment reduced airway inflammation and suppressed oxidative stress in an OVA-induced asthma model. Chronic airway inflammation is a hallmark of asthma, which is an immune-based disease. We evaluated the ability of saucerneol D, a tetrahydrofuran-type sesquilignan isolated from Saururus chinensis, to regulate airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Furthermore, we determined whether heme oxygenase (HO)-1 was required for the protective activity of saucerneol D. The airways of OVA-sensitized mice exposed to an OVA challenge developed eosinophilia and mucus hypersecretion and exhibited increased cytokine levels. Mice were administered saucerneol D orally at doses of 20 and 40 mg/kg once daily on days 26-30. Saucerneol D administered orally significantly inhibited the number of OVA-induced inflammatory cells and the production of immunoglobulin E as well as Th2-type cytokines. Histopathology studies revealed a marked decrease in lung inflammation and goblet cell hyperplasia after saucerneol D treatment. In addition, saucerneol D induced HO-1 and led to a marked decrease in OVA-induced reactive oxygen species and malondialdehyde and an increase in superoxide dismutase and glutathione in lung tissues. These antioxidant effects were correlated with HO-1 induction. In our experiments, saucerneol D treatment reduced airway inflammation and suppressed oxidative stress in an OVA-induced asthma model. |
Author | Son, Hwa-Young Cho, Eun-Sang Lee, Mee-Young Lee, Kyoung-youl Jung, Dayoung Jung, Ju-Young |
Author_xml | – sequence: 1 givenname: Ju-Young surname: Jung fullname: Jung, Ju-Young organization: Research Institute of Veterinary Medicine and College of Veterinary Medicine, Chungnam National University, Daejeon, Korea – sequence: 2 givenname: Kyoung-youl surname: Lee fullname: Lee, Kyoung-youl organization: Department of Health, Kongju National University, Gongju, Korea – sequence: 3 givenname: Mee-Young surname: Lee fullname: Lee, Mee-Young organization: Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, Daejeon, Korea – sequence: 4 givenname: Dayoung surname: Jung fullname: Jung, Dayoung organization: Department of Pharmacology, Chungnam National University, Daejeon, Korea – sequence: 5 givenname: Eun-Sang surname: Cho fullname: Cho, Eun-Sang organization: Research Institute of Veterinary Medicine and College of Veterinary Medicine, Chungnam National University, Daejeon, Korea – sequence: 6 givenname: Hwa-Young surname: Son fullname: Son, Hwa-Young email: hyson@cnu.ac.kr organization: Research Institute of Veterinary Medicine & Department of New Drug Discovery and Development, Chungnam National University, Daejeon, Korea |
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Keywords | Saucerneol D Eosinophilia Cytokine Heme oxygenase-1 Asthma Lung disease Animal model Enzyme Respiratory disease Rodentia Heme oxygenase (decyclizing) Hemopathy Inflammation Antiasthma agent Antioxidant Respiratory system Respiratory tract Vertebrata Mammalia Mouse Heat shock protein Bronchus disease Obstructive pulmonary disease Oxidoreductases |
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Snippet | Chronic airway inflammation is a hallmark of asthma, which is an immune-based disease. We evaluated the ability of saucerneol D, a tetrahydrofuran-type... |
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SubjectTerms | Animals Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - chemistry Antioxidants - administration & dosage Antioxidants - chemistry Asthma Asthma - drug therapy Asthma - immunology Biological and medical sciences Cells, Cultured Chronic obstructive pulmonary disease, asthma Cytokine Cytokines - genetics Cytokines - metabolism Disease Models, Animal Eosinophilia Female Hematologic and hematopoietic diseases Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - metabolism Heme oxygenase-1 Humans Immunoglobulin E - biosynthesis Immunoglobulin E - blood Immunoglobulin E - genetics Lignans - administration & dosage Lignans - chemistry Lignans - pharmacology Medical sciences Mice Mice, Inbred BALB C Other diseases. Hematologic involvement in other diseases Pharmacology. Drug treatments Pneumology Pneumonia - chemically induced Pneumonia - drug therapy Pneumonia - immunology Reactive Oxygen Species - metabolism Saucerneol D Saururaceae - immunology Saururus Th1-Th2 Balance - drug effects |
Title | Antioxidant and antiasthmatic effects of saucerneol D in a mouse model of airway inflammation |
URI | https://dx.doi.org/10.1016/j.intimp.2011.01.015 https://www.ncbi.nlm.nih.gov/pubmed/21295171 https://search.proquest.com/docview/866048192 https://search.proquest.com/docview/874182058 |
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