Antioxidant and antiasthmatic effects of saucerneol D in a mouse model of airway inflammation

• Published in: International immunopharmacology Vol. 11; no. 6; pp. 698 - 705
• Main Authors: Jung, Ju-Young, Lee, Kyoung-youl, Lee, Mee-Young, Jung, Dayoung, Cho, Eun-Sang, Son, Hwa-Young
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.06.2011; Elsevier
• Subjects: Animals; Anti-Asthmatic Agents - administration & dosage; Anti-Asthmatic Agents - chemistry; Antioxidants - administration & dosage; Antioxidants - chemistry; Asthma; Asthma - drug therapy; Asthma - immunology; Biological and medical sciences; Cells, Cultured; Chronic obstructive pulmonary disease, asthma; Cytokine; Cytokines - genetics; Cytokines - metabolism; Disease Models, Animal; Eosinophilia; Female; Hematologic and hematopoietic diseases; Heme Oxygenase (Decyclizing) - genetics; Heme Oxygenase (Decyclizing) - metabolism; Heme oxygenase-1; Humans; Immunoglobulin E - biosynthesis; Immunoglobulin E - blood; Immunoglobulin E - genetics; Lignans - administration & dosage; Lignans - chemistry; Lignans - pharmacology; Medical sciences; Mice; Mice, Inbred BALB C; Other diseases. Hematologic involvement in other diseases; Pharmacology. Drug treatments; Pneumology; Pneumonia - chemically induced; Pneumonia - drug therapy; Pneumonia - immunology; Reactive Oxygen Species - metabolism; Saucerneol D; Saururaceae - immunology; Saururus; Th1-Th2 Balance - drug effects; Saucerneol D; Eosinophilia; Cytokine; Heme oxygenase-1; Asthma; Lung disease; Animal model; Enzyme; Respiratory disease; Rodentia; Heme oxygenase (decyclizing); Hemopathy; Inflammation; Antiasthma agent; Antioxidant; Respiratory system; Respiratory tract; Vertebrata; Mammalia; Mouse; Heat shock protein; Bronchus disease; Obstructive pulmonary disease; Oxidoreductases
• ISSN: 1567-5769; 1878-1705
• DOI: 10.1016/j.intimp.2011.01.015

Chronic airway inflammation is a hallmark of asthma, which is an immune-based disease. We evaluated the ability of saucerneol D, a tetrahydrofuran-type sesquilignan isolated from Saururus chinensis, to regulate airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Furthermore, we determined whether heme oxygenase (HO)-1 was required for the protective activity of saucerneol D. The airways of OVA-sensitized mice exposed to an OVA challenge developed eosinophilia and mucus hypersecretion and exhibited increased cytokine levels. Mice were administered saucerneol D orally at doses of 20 and 40 mg/kg once daily on days 26–30. Saucerneol D administered orally significantly inhibited the number of OVA-induced inflammatory cells and the production of immunoglobulin E as well as Th2-type cytokines. Histopathology studies revealed a marked decrease in lung inflammation and goblet cell hyperplasia after saucerneol D treatment. In addition, saucerneol D induced HO-1 and led to a marked decrease in OVA-induced reactive oxygen species and malondialdehyde and an increase in superoxide dismutase and glutathione in lung tissues. These antioxidant effects were correlated with HO-1 induction. In our experiments, saucerneol D treatment reduced airway inflammation and suppressed oxidative stress in an OVA-induced asthma model.