Proteases in bacterial pathogenesis

Bacterial pathogens rely on proteolysis for protein quality control under adverse conditions experienced in the host, as well as for the timely degradation of central virulence regulators. We have focused on the contribution of the conserved Lon, Clp, HtrA and FtsH proteases to pathogenesis and have...

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Bibliographic Details
Published inResearch in microbiology Vol. 160; no. 9; pp. 704 - 710
Main Authors Ingmer, Hanne, Brøndsted, Lone
Format Journal Article
LanguageEnglish
Published France Elsevier SAS 01.11.2009
Subjects
ATP-Dependent Proteases - metabolism
Bacteria
Bacteria - enzymology
Bacteria - pathogenicity
Bacterial Proteins - metabolism
Endopeptidase Clp - metabolism
Heat-Shock Proteins - metabolism
Lon, Clp, HtrA and FtsH proteases
Pathogenesis
Peptide Hydrolases - metabolism
Periplasmic Proteins - metabolism
Protease La - metabolism
Quorum Sensing
Serine Endopeptidases - metabolism
Stress, Physiological
Type III secretion
Virulence Factors - metabolism
Virulence regulators
Quorum sensing
Type III secretion
Lon, Clp, HtrA and FtsH proteases
Pathogenesis
Virulence regulators
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Summary:Bacterial pathogens rely on proteolysis for protein quality control under adverse conditions experienced in the host, as well as for the timely degradation of central virulence regulators. We have focused on the contribution of the conserved Lon, Clp, HtrA and FtsH proteases to pathogenesis and have highlighted common biological processes for which their activities are important for virulence.
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ISSN:0923-2508
1769-7123
DOI:10.1016/j.resmic.2009.08.017