The Intake of Dietary Lipids Improves Glucose Tolerance via Modulating Gut Microbiota

The composition of gut microbiota is determined not only by genetic factors but also by environmental factors, such as diet, exercise, and disease conditions. Among these factors, diet is crucial in changing the gut microbial composition. Dietary lipids composed of different fatty acids not only alt...

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Published inJournal of Nutritional Science and Vitaminology Vol. 70; no. 4; pp. 336 - 343
Main Authors HANEISHI, Yuri, WATANABE, Saya, OKADA, Ayana, TAKEMAE, Hitoshi, BASTONI, Deborah, TREPPICCIONE, Lucia, SAGGESE, Anella, MIZUTANI, Tetsuya, ROSSI, Mauro, MIYAMOTO, Junki
Format Journal Article
LanguageEnglish
Published Japan Center for Academic Publications Japan 31.08.2024
Subjects
Animals
Bacteria - classification
Blood Glucose - metabolism
Diet - methods
Dietary Fats - administration & dosage
dietary lipids
energy homeostasis
fatty acids
Gastrointestinal Microbiome - drug effects
Gastrointestinal Microbiome - physiology
Glucose - metabolism
Glucose Intolerance
glucose tolerance
Glucose Tolerance Test
gut microbiota
Male
Mice
Mice, Inbred C57BL
dietary lipids
fatty acids
glucose tolerance
energy homeostasis
gut microbiota
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Summary:The composition of gut microbiota is determined not only by genetic factors but also by environmental factors, such as diet, exercise, and disease conditions. Among these factors, diet is crucial in changing the gut microbial composition. Dietary lipids composed of different fatty acids not only alter host metabolism but also have a significant impact on the composition of gut microbiota. However, the molecular mechanisms underlying the relationship between these host effects and their impact on gut microbiota remain unclear. Here, we demonstrated that intake of different dietary lipids improved glucose tolerance by modulating gut microbiota. The results of our analysis show that the taxa of bacteria that increase in number as a result of dietary lipid intake play an important role in glucose metabolism. Thus, we have identified a new mechanism underlying the function of dietary lipids in regulating glucose homeostasis. Our findings contribute to possible new methods to prevent and treat metabolic disorders by modifying the composition of gut microbiota.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.70.336