Assessment of Insulin Resistance in Acromegaly Associated with Diabetes Mellitus before and after Transsphenoidal Adenomectomy

With a euglycemic hyperinsulinemic clamp method, whole-body insulin resistance was assessed in 6 cases with acromegaly associated with diabetes mellitus before and after transsphenoidal adenomectomy. The glucose infusion rate (GIR) correlated well with the plasma IGF-I level but poorly with that of...

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Published inEndocrine Journal Vol. 44; no. 4; pp. 617 - 620
Main Authors WASADA, TARO, AOKI, KAORI, SATO, AKIKO, KATSUMORI, KOZO, MUTO, KAZUKO, TOMONAGA, OSAMU, YOKOYAMA, HIROKI, IWASAKI, NAOKO, BABAZONO, TETSUYA, TAKAHASHI, CHIEKO, IWAMOTO, YASUHIKO, OMORI, YASUE, HIZUKA, NAOMI
Format Journal Article
LanguageEnglish
Published Japan The Japan Endocrine Society 01.08.1997
Subjects
Acromegaly
Acromegaly - physiopathology
Adenoma - surgery
Adenomectomy
Adult
Diabetes Mellitus - physiopathology
Evaluation Studies as Topic
Female
Humans
IGF-1
Insulin resistance
Insulin Resistance - physiology
Male
Middle Aged
Pituitary Neoplasms - surgery
Sphenoid Sinus
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Summary:With a euglycemic hyperinsulinemic clamp method, whole-body insulin resistance was assessed in 6 cases with acromegaly associated with diabetes mellitus before and after transsphenoidal adenomectomy. The glucose infusion rate (GIR) correlated well with the plasma IGF-I level but poorly with that of GH. Further improvement in insulin sensitivity occurred 3-4 months after operation without substantial changes in plasma levels of both GH and IGF-I or glycemic control. These results indicate that GH excess can induce insulin resistance in association with plasma IGF-1 and also through undefined secondary effect.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.44.617