SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma

Sterol regulatory element binding protein 1c (SREBP-1c) promotes lipogenesis and tumor growth in various cancers. It is well known that clear cell renal cell carcinoma (ccRCC), a major subtype of the kidney cancers, exhibits elevated lipid accumulation. However, it has not been fully understood how...

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Bibliographic Details
Published inBioscience reports Vol. 37; no. 6
Main Authors Sethi, Gautam, Shanmugam, Muthu K, Kumar, Alan Prem
Format Journal Article
LanguageEnglish
Published England Portland Press Ltd 22.12.2017
Subjects
Carcinogenesis - genetics
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - pathology
Cell Cycle - genetics
Humans
Lipid Metabolism - genetics
Lipogenesis - genetics
Liver - metabolism
Review
Sterol Regulatory Element Binding Protein 1 - genetics
SREBP-1c
renal cell carcinoma
lipogenesis
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Summary:Sterol regulatory element binding protein 1c (SREBP-1c) promotes lipogenesis and tumor growth in various cancers. It is well known that clear cell renal cell carcinoma (ccRCC), a major subtype of the kidney cancers, exhibits elevated lipid accumulation. However, it has not been fully understood how lipid metabolism might be associated with cell cycle regulation in ccRCC. In a recent issue, Lee et al. (Molecular and Cellular Biology (2017) pii: MCB.00265-17) demonstrate that SREBP-1c is up-regulated in ccRCC by ring finger protein 20 (RNF20) down-regulation, leading to aberrant lipid storage and pituitary tumor transforming gene 1 ( )-dependent cell cycle progression. These findings suggest that SREBP-1c serves as a molecular bridge between lipid metabolism and cell cycle control in ccRCC tumorigenesis.
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ISSN:0144-8463
1573-4935
DOI:10.1042/bsr20171270